Practical Hemostasis and Thrombosis

Nigel S. Key, Harold R. Roberts Distinguished Professor, Division of Hematology and Oncology, Department of Medicine, University of North Carolina School of Medicine, North Carolina, Chapel Hill, USA Michael Makris, Senior Lecturer in Haematology, Department of Medicine and Pharmacology, University of Sheffield, Sheffield, UK David Lillicrap, Professor of Hematology, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, Ontario, Canada

List of Contributors ix 1 Basic Principles Underlying Coagulation 1 Dougald M. Monroe 2 Laboratory Tests of Hemostasis 12 Steve Kitchen and Michael Makris 3 Molecular Diagnostic Approaches to Hemostasis 27 Paula James and David Lillicrap 4 Tests of Platelet Function 42 Marie Lordkipanidze, Gillian C. Lowe and Paul Harrison 5 Evaluation of the Bleeding Patient 63 Alice Ma and Marshall Mazepa 6 Hemophilia A and B 79 Rhona M. Maclean and Michael Makris 7 Von Willebrand disease 94 Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero 8 The Rarer Inherited Coagulation Disorders 113 Paula H.B. Bolton -Maggs, Jonathan Wilde and Gillian N. Pike 9 Acquired Inhibitors of Coagulation 124 Riitta Lassila and Elina Armstrong 10 Quantitative Platelet Disorders 134 Riten Kumar and Walter H.A. Kahr 11 Qualitative Platelet Disorders 160 Eti A. Femia Gian Marco Podda and Marco Cattaneo 12 Disseminated Intravascular Coagulation 172 Raj S. Kasthuri and Nigel S. Key 13 Thrombotic Microangiopathies 183 Marie Scully and David Kavanagh 14 Venous Thromboembolism 195 Sarah Takach Lapner, Lori-Ann Linkins and Clive Kearon 15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210 Brandi Reeves and Stephan Moll 16 Arterial Thrombosis 229 R. Campbell Tait and Catherine N. Bagot 17 Anticoagulation: Heparins and Vitamin K Antagonists 240 Gualtiero Palareti and Benilde Cosmi 18 The Direct Oral Anticoagulants 253 David A. Garcia, Mark A. Crowther and Walter Ageno 19 Antiphospholipid Syndrome 269 Henry G. Watson and Mark Crowther 20 Cardiovascular Medicine 282 Sreekanth Vemulapalli and Richard C. Becker 21 Cardiothoracic Surgery 299 Denise O Shaughnessy and Ravi Gill 22 Neurology 314 Michael Wang, Natalie Aucutt-Walter, Valerie L. Jewells and David Y. Huang 23 Hepatology 329 Lara N. Roberts, Raj K. Patel and Roopen Arya 24 Nephrology 340 Vimal K. Derebail and Thomas L. Ortel 25 Oncology 355 Anna Falanga and Marina Marchetti 26 Obstetrics, Contraception, and Estrogen Replacement 379 Amy Webster and Sue Pavord 27 Pediatrics 393 Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte 28 Intensive and Critical Care 414 Beverley J. Hunt 29 Transfusion 433 Adrian Copplestone Appendix 1 Reference Ranges 444 Steve Kitchen and Michael Makris Index 452