TNM Classification of Malignant Tumours

James D. Brierley, BSc, MB, FRCP, FRCR, FRCPC Professor, Department of Radiation Oncology, Princess Margaret Cancer Centre and the University of Toronto, Canada
Dr Brierley trained in Clinical Oncology in the UK and developed his interest in cancer staging and surveillance when moving to Canada and has been involved in cancer surveillance, locally, nationally and internationally. He is Co-Chair of the UICC TNM Prognostic Factors Project. He has co-edited the TNM Supplement 4th edition (Wiley 2012) and the UICC Manual of Clinical Oncology (Wiley 2015).

Mary K. Gospodarowicz MD, FRCPC, FRCR (Hon) Medical Director, Princess Margaret Cancer Centre, University Health Network; Regional Vice-President of Cancer Care Ontario for Toronto South; Toronto, Ontario, Canada
Dr Gospodarowicz is the Past-President of UICC. She has a long-standing interest in cancer classification with an emphasis on staging and prognostic factors and she has been involved in the UICC TNM Project for many years. Her interests include the application of modern information and communication technologies in cancer control. Dr Gospodarowicz was coeditor of the 7th edition of the TNM Classification of Malignant Tumours (Wiley 2009) and editor of the 2nd and 3rd editions of the UICC Prognostic Factors in Cancer (Wiley 2001, 2006).

Christian Wittekind MD Professor of Pathology, Chairman Institute of Pathology, University of Leipzig, Germany Dr Wittekind been involved in cancer staging and tumour classifications for over 20 years. He is a member of the UICC TNM Core Committee, Head of the German Speaking TNM-Komittee, and personally responds to all the questions to the UICC TNM helpdesk. He was the coeditor of the 5th , 6th and 7th edition of the TNM classification of Malignant Tumours (Wiley 1997, 2002, 2009) editor of the 2nd, 3rd, and 4th edition of the TNM Supplement (Wiley 2001, 2003 and 2012) and editor of the 6th edition of the TNM Atlas (Wiley 2014).

Preface

Acknowledgments

Organizations Associated with the TNM System

Members of UICC Committees Associated with the TNM System

Section Editors

Introduction

Head and Neck Tumours

Lip and Oral Cavity

Pharynx

Larynx

Nasal Cavity and Paranasal Sinuses

Unknown Primary - Cervical Nodes

Malignant Melanoma of Upper Aerodigestive Tract

Major Salivary Glands

Thyroid Gland

Digestive System Tumours

Oesophagus and Oesophagogastric Junction

Stomach

Small Intestine

Appendix

Colon and Rectum

Anal Canal and Perianal Skin

Liver

Intrahepatic Bile Ducts

Gallbladder

Perihilar Bile Ducts

Distal Extrahepatic Bile Duct

Ampulla of Vater

Pancreas

Well-Differentiated Neuroendocrine Tumours of the Gastrointestinal Tract

Lung, Pleural, and Thymic Tumours

Lung

Pleural Mesothelioma

Thymic Tumours

Tumours of Bone and Soft Tissues

Bone

Soft Tissues

Gastrointestinal Stromal Tumour (GIST)

Skin Tumours

Carcinoma of Skin

Skin Carcinoma of the Head and Neck

Carcinoma of Skin of the Eyelid

Malignant Melanoma of Skin

Merkel Cell Carcinoma of Skin

Breast Tumours

Gynaecological Tumours

Vulva

Vagina

Cervix Uteri

Uterus - Endometrium

Uterine Sarcomas

Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma

Gestational Trophoblastic Neoplasms

Urological Tumours

Penis

Prostate

Testis

Kidney

Renal Pelvis and Ureter

Urinary Bladder

Urethra

Adrenal Cortex

Ophthalmic Tumours

Carcinoma of Conjunctiva

Malignant Melanoma of Conjunctiva

Malignant Melanoma of Uvea

Retinoblastoma

Sarcoma of Orbit

Carcinoma of Lacrimal Gland

Hodgkin Lymphoma

Non-Hodgkin Lymphomas

Essential TNM

Paediatric Tumours

Gastrointestinal Tumours

Bone and Soft Tissue Tumours

Gynaecological Tumours

Urological Tumours

Ophthalmic Tumours

Malignant Lymphoma

Central Nervous System