Pancreatitis – Medical and Surgical Management

David B. Adams, M.D. is Professor and Chief of Gastrointestinal and Laparoscopic Surgery and Co-Director of the Digestive Disease Center at the Medical University of South Carolina, Charleston, South Carolina. He is the author of over 100 manuscripts and book chapters which deal with his academic and clinical research interests in chronic pancreatitis. Peter B. Cotton, M.D. is a British Gastroenterologist best known for his advancement in digestive disease, pioneering and naming the ERCP procedure and creating the Digestive Disease Center at the Medical University of South Carolina where he is Professor of Medicine. He has been active in National and International organizations, and has given invited lectures and demonstrations in more than 50 countries His bibliography includes over 900 medical publications, including more than 300 original contributions in peer reviewed journals, and 10 books. Nicholas J. Zyromski, M.D. is Associate Professor of Surgery at Indiana University. He served as an NIH research fellow at the Mayo Clinic in Rochester, Minnesota, and is currently the Indiana University HPB Surgery Fellowship Program Director. Dr. Zyromski's principal clinical interest is in pancreatic disease; his basic and translational research interest focuses on the inflammatory response of acute pancreatitis as well as the influence of obesity and adipose tissue on pancreatic diseases -- pancreatic cancer and acute pancreatitis. John Windsor, M.D. holds a personal chair in surgery at the University of New Zealand, Auckland. He is Director of Surgical Research, Director of Surgical Research Network, Co-Director of Applied Surgery and Metabolism Laboratory and Surgical Centre for Outcomes Research and Evaluation, Principle Investigator Pancreas Research Group, and Associate Investigator Maurice Wilkins Centre of Biodiscovery. His primary research is in the pathophysiology and clinical management of acute and chronic pancreatitis. He is Associate Editor of the journal Pancreatology and the World Journal of Surgery.

List of contributors, vii 1 Epidemiology and genetics of chronic pancreatitis, 1 2A Pathobiology of the acinar cell in acute pancreatitis, 10 2B Locoregional pathophysiology in acute pancreatitis: pancreas and intestine, 19 2C Pathophysiology of systemic inflammatory response syndrome and multiorgan dysfunction syndrome in acute pancreatitis, 29 3 Diagnosis, prediction, and classification, 38 4 Medical treatment, 47 5 Nutritional treatment in acute pancreatitis, 55 6 Gallstone pancreatitis: diagnosis and treatment, 64 7 Treatment of local complications, 75 8 Treatment of systemic complications and organ failure, 85 9 Specific treatment for acute pancreatitis, 91 10 Sequelae of acute pancreatitis, 101 11 History of chronic pancreatitis, 113 12A Epidemiology and pathophysiology: epidemiology and risk factors, 118 12B Epidemiology and pathophysiology: genetic insights into pathogenesis, 126 12C Pancreatic stellate cells: what do they tell us about chronic pancreatitis?, 143 12D Autoimmune pancreatitis: an update, 152 12E Etiology and pathophysiology: tropical pancreatitis, 161 12F Mechanisms and pathways of pain in chronic pancreatitis, 169 13A Imaging of chronic pancreatitis, 179 13B Endoscopic ultrasonography in chronic pancreatitis, 188 14A Pancreatic enzyme replacement therapy (PERT), 195 14B Nutritional treatment: antioxidant treatment, 205 14C Pancreatogenic diabetes: etiology, implications, and management, 211 14D Nutrition without a pancreas: how does the gut do it?, 225 15A Endoscopic management of chronic pancreatitis, 233 15B Shocking and fragmenting pancreatic ductal stones, 245 15C Endoscopic management: celiac plexus blockade, 249 16A A brief history of modern surgery for chronic pancreatitis, 256 16B Surgery for chronic pancreatitis: indications and timing of surgery, 261 16C Chronic pancreatitis: surgical strategy in complicated diseases, 265 16D Surgery for chronic pancreatitis: pancreatic duct drainage procedures, 273 16E Surgical management: resection and drainage procedures, 279 16F The role of pancreatoduodenectomy in the management of chronic pancreatitis, 286 17A Total pancreatectomy and islet cell autotransplantation: patient selection, 295 17B Total pancreatectomy and islet cell autotransplantation: the science of islet cell preservation, from pancreas to liver, 299 17C Total pancreatectomy and islet cell autotransplantation: long-term assessment of graft function, 308 Index, 321