Renal Cell Carcinoma

Ronald M Bukowski MD Emeritus Staff Physician Cleveland Clinic Taussig Cancer Center Professor Emeritus of Medicine CCF Lerner College of Medicine of CWRU Robert Figlin MD Professor of Medicine and Biomedical Sciences Director, Division of Hematology Oncology Department of Medicine, Cedars-Sinai Medical Center Associate Director for Academic Programs Samuel Oschin Comprehensive Cancer Institute Professor Emeritus of Medicine and Urology David Geffen School of Medicine at UCLA Robert Motzer MD Attending Physician Department of Medicine Memorial Sloan-Kettering Cancer Center Professor of Medicine Weil Medical College of Cornell University

Ch. 1: Targeted Therapy for Metastatic Renal Cell Carcinoma : the First Ten Years; Ch. 2: RCC: Pathologic and Molecular assessment of Targets; Ch. 3: Targeted Therapy for Metastatic Renal Cell Carcinoma : the First Ten Years; Ch. 4: VHL and HIF in clear cell Renal Cell Carcinoma: Molecular Abnormalities and Potential Clinical Applications; Ch. 5: PBRM1: A Critical Subunit of the SWI/SNF Chromatin Remodeling Complex; Ch. 6: Sporadic RCC – Abnormalities in Histone Modifying Genes; 7: Genetic Heterogeneity in Renal Cell Carcinoma: Clinical Implications?; Ch. 8: First-Generation Tyrosine Kinase Inhibitors – Clinical Results;  9: Second Generation Tyrosine Kinase Inhibitors (Pazopanib) in Renal Cell Carcinoma: Current Status; Ch. 10: Third Generation TKIs (Axitinib, Tivozanib) in RCC: enhanced efficacy and diminished toxicity?; Ch. 11: Anti-VEGF and VEGFR monoclonal antibodies in RCC; Ch. 12: PI3-Kinase, Akt, and mTOR Inhibitors in RCC; Ch. 13: Carbonic anhydrase IX & Monoclonal Antibody G250: relevance as a clinical and biologic target in Renal Cell Carcinoma; Ch. 14: EGFR and HER2: Relevance in Renal Cell Carcinoma; Ch. 15: The Role of Hepatocyte Growth Factor Pathway Signaling in Renal Cell Carcinoma; Ch. 16: Development of Resistance to Targeted Therapy: Preclinical Findings and Clinical Relevance; Ch. 17: Development of Combination Therapy with Targeted Agents; Ch. 18: Side Effects ofTargeted Thearpy; Ch. 19: The Role of Targeted Therapy in Special Populations; Ch. 20: Immunotherapy: the Current Role of Cytokines; Ch. 21: Immune Checkpoint Inhibitors (anti-CTLA4, anti PD-1) in RCC; Ch. 22: Vaccines in RCC: Clinical and Biological Relevance; Ch. 23: Development and Incorporation of Biomarkers in RCC Therapeutics; Ch. 24: Molecularly Targeted Staging Strategies in Renal Cell Carcinoma; Ch. 25: Clinical Prognostic Factors in Metastatic Renal Cell Carcinoma; Ch. 26: The Role of Advocacy in Renal Cell Carcinoma