TRP Channels in Drug Discovery

Introduction to TRPs: A Quest for Novel Drug Targets.- TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development.- TRPA1 in Drug Discovery.- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases.- TRPM2 Function and Potential as a Drug Target.- The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5.- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis.- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation.- TRPML Channels in Function, Disease, and Prospective Therapies.- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1.- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities.- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”.- TRPV4 and Drug Discovery.- TRP Expression and Function in the Lung Airways.- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells.- Endotoxin-Induced Airway Inflammation and Asthma Models.- Enhanced Cough, Animal Models.- Capsaicin Inhalation Test in Man.- TRP Channels in the Genitourinary (GU) Tract.- Animal Models of Cystitis.- Overactive Bladder Models.