Neurology (eBook)

Dr Charles Clarke has been a consultant neurologist since 1979 and now works at the National Hospital and Whipps Cross Hospital, London. He is the author of Neurological Diseases in Clinical Medicine (editors: Parveen Kumar and Michael Clark; publishers: Elsevier). The sixth edition is now in press. He has been closely involved in the book, written originally by consultants at St Bartholomew's Hospital, since the first edition in 1987. Dr Robin Howard has been consultant neurologist at the National Hospital and St Thomas' Hospital since 1992. He has a large general neurology NHS practice and is consultant to three neurological intensive care units as well as directing clinical services for patients with motor neurone disease, myasthenia gravis and sleep disorders. He has written extensively - more than 100 peer reviewed papers and 30 review articles/book chapters. Professor Martin Rossor has been in consultant practice since 1986. He is Professor of Neurology at the Institute of Neurology, honorary consultant neurologist at the National Hospital and St Mary's Hospital. His particular clinical and personal interests are degenerative dementias and cognitive neurology. Professor Simon Shorvon was appointed consultant neurologist at the National Hospital in 1983. His special interests are in epilepsy, imaging and epidemiology. He was previously Medical Director of the National Society for Epilepsy, the leading UK charity in the field of epilepsy and Chairman of the University Department of Neurology in UCL. He has published over 250 peer reviewed articles and 100 chapters and books.

Editorial Team vii

Principal Editors vii

International Editors vii

Specialist Advisory Editors vii

Authors vii

Beginnings xi

Foreword to the First Edition xiii

Foreword to the Second Edition xv

Preface xvii

Acknowledgements xix

1 Neurology Worldwide: The Epidemiology and Burden of Neurological Disease 1
Simon Shorvon

2 Nervous System Structure and Function 11
Charles Clarke and Roger Lemon

3 Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels 69
Dimitri Kullmann, Henry Houlden and Michael Lunn

4 The Language of Neurology: Symptoms, Signs and Basic Investigations 97
Charles Clarke, Matthew Adams, Robin Howard, Martin Rossor, Simon Shorvon and Jason Warren

5 Stroke and Cerebrovascular Diseases 133
Nicholas Losseff, Matthew Adams, Martin M. Brown, Joan Grieve and Robert Simister

6 Movement Disorders 187
Kailash Bhatia, Carla Cordivari, Mark Edwards, Thomas Foltynie, Marwan Hariz, Prasad Korlipara, Patricia Limousin, Niall Quinn, Sarah Tabrizi and Thomas Warner

7 Epilepsy and Related Disorders 221
Simon Shorvon, Beate Diehl, John Duncan, Matthias Koepp, Fergus Rugg-Gunn, Josemir Sander, Matthew Walker and Tim Wehner

8 Dementia and Cognitive Impairment 289
Martin Rossor, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Jonathan Schott and Jason Warren

9 Infection in the Nervous System 337
Robin Howard, Carmel Curtis and Hadi Manji

10 Nerve and Muscle Disease 391
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Shamima Rahman, Mary Reilly, Katie Sidle and Christopher Turner

11 Multiple Sclerosis and Demyelinating Diseases 475
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller and Alan Thompson

12 Headache 513
Manjit Matharu, Paul Shanahan and Tim Young

13 Cranial Nerve Disorders 531
Jeremy Chataway, Charles Clarke, Robin Howard and Paul Jarman

14 Neuro-Ophthalmology 553
James Acheson, Fion Bremner, Elizabeth Graham, Robin Howard, Alexander Leff, Gordon Plant, Simon Shorvon and Ahmed Toosy

15 Neuro-Otology: Problems of Dizziness, Balance and Hearing 605
Rosalyn Davies, Linda M. Luxon, Doris-Eva Bamiou and Adolfo Bronstein

16 Spinal Column and Spinal Cord Disorders 647
Simon Farmer and David Choi

17 Cerebellar Ataxias and Related Conditions 685
Nicholas W. Wood

18 Restorative Neurology, Rehabilitation and Brain Injury 699
Richard Greenwood, Diana Caine, Ulrike Hammerbeck, Alexander Leff, Diane Playford, Valerie Stevenson and Nick Ward

19 Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism 729
Robin Howard, Jeremy Chataway, Mark Edwards, Simon Heales, Robin Lachmann, Alexander Leff and Elaine Murphy

20 Disorders of Consciousness, Intensive Care Neurology and Sleep 797
Robin Howard, Sofia Eriksson, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Christopher Taylor and Matthew Walker

21 Neuro-Oncology 849
Jeremy Rees, Robert Bradford, Sebastian Brandner, Naomi Fersht, Rolf Jäger and Elena Wilson

22 Neuropsychiatry 905
Eileen Joyce

23 Pain 919
Paul Nandi

24 Autonomic Aspects of Neurology 945
Christopher Mathias, Gordon Ingle and Valeria Iodice

25 Uroneurology 967
Jalesh Panicker

26 Systemic Conditions and Neurology 985
David Werring, Robin Howard and Simon Shorvon

Index 1029