The Physical Basis of Biochemistry

Principles of Biophysical Inquiry.- Introduction: To the Student – First Edition.- Philosophy and Practice of Biophysical Study.- Overview of the Biological System Under Study.- Physical Thoughts, Biological Systems – The Application of Modeling Principles to Understanding Biological Systems.- Probability and Statistics.- Foundations.- Energy and Force – The Prime Observables.- Biophysical Forces in Molecular Systems.- Physical Principles: Quantum Mechanics.- Chemical Principles.- Measuring the Energy of a System: Energetics and the First Law of Thermodynamics.- Entropy and the Second Law of Thermodynamics.- Which Way Is That System Going? The Gibbs Free Energy.- The Thermodynamics of Phase Equilibria.- Building a Model of Biomolecular Structure.- Water: A Unique Solvent and Vital Component of Life.- Ion–Solvent Interactions.- Ion–Ion Interactions.- Lipids in Aqueous Solution.- Macromolecules in Solution.- Molecular Modeling – Mapping Biochemical State Space.- The Electrified Interphase.- Function and Action Biological State Space.- Transport – A Non-equilibrium Process.- Flow in a Chemical Potential Field: Diffusion.- Flow in an Electric Field: Conduction.- Forces Across Membranes.- Kinetics – Chemical Kinetics.- Dynamic Bioelectrochemistry – Charge Transfer in Biological Systems.- Methods for the Measuring Structure and Function.- Separation and Characterization of Biomolecules Based on Macroscopic Properties.- Analysis of Molecular Structure with Electronic Spectroscopy.- Molecular Structure from Scattering Phenomena.- Analysis of Structure – Microscopy.- Epilogue.- Physical Constants.