Chordomas

Director, Skull Base Program, Lecturer, Harvard Medical SchoolDepartment of Neurosurgery, Brigham and Womens Hospital, Lecturer, Harvard School of Medicine, Boston, MA

Part I Definition, History, Demographics, Pathology, and Pathogenesis

1 Historical Aspects

2 The Descriptive Epidemiology of Chordomas

3 Evolutionary Origin of the Notochord

4 Molecular Biology of Chordomas

5 Cytogenetics of Chordomas

6 Local Invasion and Metastasis

7 Pathology

8 Experimental Models of Chordomas

Part II Diagnosis of Chordomas

9 Radiologic Findings and Differential Diagnosis of Chordomas at the Skull Base

10 Radiologic Findings and Differential Diagnosis of Chordomas in the Spine

11 Molecular Imaging of Chordomas

Part III Surgical Treatment of Chordomas

12 Surgical Decision Making in Chordomas

13 Choice of the Optimal Surgical Approach for Skull Base Chordomas

14 Anterior Approaches to the Clivus

15 Endoscopic Approaches for Skull Base Chordomas

16 Frontobasal Approaches for Skull Base Chordomas

17 Cranio-Orbital-Zygomatic Approach for Chordomas

18 Epidural Middle Fossa Approaches

19 The Extended Petrosal Middle Fossa Approach

20 The Transcondylar Approach to the Clivus

21 Craniovertebral Reconstruction after Chordoma Resection

22 Surgery for Spinal Chordomas

23 Intraoperative Assistive Technologies for Chordoma Surgery

Part IV Special Topics in Chordomas

24 Chordomas: A Personal Perspective

25 Radiation Treatment for Chordomas

26 Charged Particle Beams in Management of Clival Chordomas

27 Stereotactic Radiosurgery for Chordomas

28 Recurrence in Skull Base Chordomas and its Management

29 Outcome and Quality of Life of Patients with Chordomas

30 Chordomas and Chondrosarcomas in the Pediatric Population

31 Future Prospects in the Treatment of Skull Base Chordomas