Polymers for Biomedicine

CARMEN SCHOLZ, PhD, is a Professor in the Department of Chemistry at the University of Alabama in Huntsville, where her research concentrates on the synthesis and characterization of biocompatible and biodegradable polymers. She serves on the editorial boards of 3 journals (including Wiley's Polymer International), has published over 70 papers or proceedings, and edited 5 books.

List of Contributors ix

Part I. Pseudo-Peptides, Polyamino acids and Polyoxazolines 1

Chapter 1 - Characterization of Polypeptides and Polypeptoides­ –Methods and Challenges 3
David Huesmann and Matthias Barz

Chapter 2- Poly(2-Oxazoline): The structurally Diverse Biocompatibilizing Polymer 31
Rodolphe Obeid

Chapter 3- Poly(2-oxazoline) Polymers – synthesis, characterization and Applications in Development of Therapeutics 51
Randall W. Moreadith and Tacey X. Viegas

Chapter 4- Polypeptoid Polymers: Synthesis, Characterization and Properties 77
Brandon A. Chan, Sunting Xuan, Ang Li, Jessica M. Simpson and Donghui Zhang

Part II - Advanced Polycondensates 121

Chapter 5 - Polyanhydrides: Synthesis and Characterization 123
Rohan Ghadi, Eameema Muntimadugu Wahid Khan and Abraham J. Domb

Chapter 6 - New Routes to Tailor-Made Polyesters 149
Kazuki Fukushima and Tomoko Fujiwara

Chapter 7 - Polyphosphoesters: An old biopolymer in a new light 191
Kristin N. Bauer, Hisaschi T.C. Tee, Evandro M. Alexandrino and Frederik R. Wurm

Part III. Cationically Charged Macromolecules 243

Chapter 8 - Design and Synthesis of Amphiphilic Vinyl Copolymers with Antimicrobial Activity 245
Leanna L. Foster, Masato Mizutani, Yukari Oda, Edmund F. Palermo and Kenichi Kuroda

Chapter 9 - Enhanced Polyethylenimine-Based Delivery of Nucleic Acids 273
Jeff Sparks, Tooba Anwer and Khursheed Anwer

Chapter 10 - Cationic graft copolymers for DNA engineering 297
Atsushi Maruyama and Naohiko Shimada

Part IV. Biorelated polymers by Controlled Radical Polymerization 313

Chapter 11 - Synthesis of (Bio)degradable Polymers by Controlled/“Living” Radical Polymerization 315
Shannon R. Woodruff and Nicolay V. Tsarevsky

Part V. Polydrugs and Polyprodrugs 355

Chapter 12 - Polymerized drugs – a novel approach to controlled release systems 357
B. Demirdirek, J. J. Faig, R. Guliyev and K.E.Uhrich

Chapter 13 - Structural design and synthesis of polymer prodrugs 391
Petr Chytil, Libor Kostka and Tomáš Etrych

Part VI. Biocompatibilization of Surfaces 421

Chapter 14 - Polymeric ultrathin films for surface modifications 423
Henning Menzel

Chapter 15 - Surface Functionalization of Biomaterials by Poly(2-oxazoline)s 457
Giulia Morgese and Edmondo M. Benetti

Chapter 16 - Biorelated polymer brushes by surface initiated reversible deactivation radical polymerization 487
Rueben Pfukwa, Lebohang Hlalele and Bert Klumperman

Part VII. Self-assembled Structures and Formulations 525

Chapter 17 - Synthesis of amphiphilic invertible polymers for biomedical applications 527
A.M. Kohut, I.O. Hevus, S.A. Voronov and A.S. Voronov

Chapter 18 - Bioadhesive Polymers for Drug Delivery 559
Eenko Larrañeta and Ryan F. Donnelly

INDEX