Drug Target miRNA

MiRNA Targeting Drugs: The Next Blockbusters?.- Functional Analysis of miRNA using DIANA Tools Online Suite.- Non-Nucleotide Modification of Anti-miRNA Oligonucleotides.- Quantification of Oligonucleotide Association with miRNA-Argonaute Complexes In Vitro.- Determination of Anti-miR Association with miRNA/Argonaute Complexes In Vivo.- Competitive Argonaute-Based RNA Immunoprecipitation for Investigation of Transcriptomic Response to Anti-miR.- Assessing Anti-miR Pharmacology with miRNA Polysome Shift Assay.- Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells.- Assessing the Off-Target Effects of miRNA Inhibitors on Innate Immune Toll-Like Receptors.- Design of Multimodal Small Molecules Targeting miRNA Biogenesis: Synthesis and In Vitro Evaluation.- Machine Learning Approaches towards Building Predictive Models for Small MoleculeModulators of miRNA and its Utility in Virtual Screening of Molecular Databases.- Identification of Small Molecule Modulators of MicroRNA by Library Screening.- Rapid Generation of miRNA Inhibitor Leads by Bio-Informatics and Efficient High-Throughput Screening Methods.- Peptide-Based Inhibition of miRNA-Guided Gene Silencing.- Small Molecules Targeting the miRNA Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.- Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.- Antagonists of the miRNA-Argonaute 2 Protein Complex: Anti-miR-AGOs.- Elucidating Mechanisms of Molecular Recognition between Human Argonaute and miRNA using Computational Approaches.- Kinetic Analysis of Target RNA Binding and Slicing by Argonaute 2 Protein.- Site-Specific Fluorescent Labeling of Argonaute for FRET-Based Bio-Assays.- Single-Molecule Fluorescence Energy Transfer Assays for the Characterization of Reaction Pathways of miRNA-Argonaute Complex.