Sickle Cell Disease Patient

Part 1 Historical survey and review of the literature: historical observations; sickle cell disease in successive Ghanaian generations for 3 centuries; some general observations on the genetic expression of sickle cell disease; sickle cell disease as an haemoglobinopathy; the molecular pathology of sickle cell haemoglobin and other haemoglobin variants; genetic control of haemoglobin synthesis. Part 2 Clinical features 1: history of sickle cell disease in the world; balanced polymorphism and other factors relating to hereditary qualitative and quantitative erythrocyte defects; the pathgenesis of sickle cell disease; the crisis in sickle cell disease. Part 3 Clinical features 2: patients and methods, the sickle cell/haemoglobinopathy clinic of Korle Bu teaching hospital; rheumatism, dactylitis and seasonal epidemiology of sickle cell crises in Accra; pallor and jaundice in sickle cell disease; gnathopathy, bossing of skull bones and finger clubbing in sickle cell disease; body habitus and growth in sickle cell disease; sickle cell dermathopathy in Accra; epistaxis and haematuria - two bleeding tendencies in sickle cell states; sickle cell ophthalmopathy; sickle cell priapism; articular bone neurosis in scikle cell disease; skeletal involvement in sickle cell disease; abdominal pain in sickle cell disease; the liver in sickle cell disease; the spleen and lymphnodes in sickle cell disease; cardio-respiratory involvement in sickle cell disease; sickle cell disease and the central nervous system; some quantitative aspects of pregnancy in sickle cell disease in Accra; notes on some miscellaneous clinical features of sickle cell disease. Part 4 Some laboratory and other findings in sickle cell disease: haemotological profile in sickle cell disease; percentage values of haemoglobins S,F,A2,C and A is various sickle cell phenotypes and the position of the sickle cell trait; some aspects of renal function in sickle cell disease; some radio-active isotope patterns of sickle cell disease in Accra. Part 5 Management and conclusions: an approach to the treatment of sickle cell disease; the prognostic and public health aspects of sickle cell disease in Accra; the socio-politics of "Sickle Cell"; conclusions - the whole person. Appendices: Case histories; some laboratory investigations; Korle Bu hospital schedule for emergency treatment of sickle cell crisis; list of some sickle cell disease patient orientated centres in the world.