Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Novel Platinum Analogues, Original Formulations and Other Heavy Metals.- Platinum Compounds: The Culmination of the Era of Cancer Chemotherapy.- Studies on New Platinum Compounds.- Assessment of the In Vivo Antiproliferative Activity of a Novel Platinum Particulate Pharmacophore.- Nanocapsules of Platinum-Based Anticancer Drugs.- The Design and Development of the Tumor-Targeting Nanopolymer Dach Platinum Conjugate AP5346 (Prolindac™).- In vitro Anti-proliferative Effects of ProLindac™, a Novel Dach-Platinum-Linked Polymer Compound, as a Single Agent and in Combination with Other Anti-cancer Drugs.- Synthesis of Cisplatin Analogues: Cytotoxic Efficacy and Anti-tumour Activity of Bis-Amidine and Bis-Iminoether Pt(II) Complexes.- Ruthenium Drugs for Cancer Chemotherapy: An Ongoing Challenge to Treat Solid Tumours.- X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex.- Osmium Arenes: A New Class of Potential Anti-cancer Agents.- Cellular Transport and Intracellular Trafficking of Platinum Compounds.- Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells.- CTR1 as a Determinant of Platinum Drug Transport.- Regulation of the Export of Platinum-Containing Drugs by the Copper Efflux Transporters ATP7A and ATP7B.- Altered Localization of Transport Proteins Associated with Cisplatin Resistance.- How to Overcome Cisplatin Resistance Through Proton Pump Inhibitors.- Cellular Resistance to Oxaliplatin and Drug Accumulation Defects.- Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action.- DNA Damage and Signal Transduction: Recognition/Repair And Cell-Response.- Structural and Mechanistic Studies ofAnticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding.- Platinum Drugs and DNA Repair: Lessons from the NCI Panel and Clinical Correlates.- Differences in Conformation and Conformational Dynamics Between Cisplatin and Oxaliplatin DNA Adducts.- Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest.- Targeting Nucleotide Excision Repair as a Mechanism to Increase Cisplatin Efficacy.- CHK2 and ERCC1 in the DNA Adduct Repair Pathway that Mediates Acquired Cisplatin Resistance.- Modulation of Survival Pathways in Ovarian Carcinoma Cells Resistant to Platinum Compounds.- Paraptotic Cell Death Induced by the Thioxotriazole Copper Complex A0: A New Tool to Kill Apoptosis-Resistant Cancer Cells.- Clinical Applications.- Platinum Compounds and Radiation.- Treating Cisplatin-Resistant Cancer: A Systematic Analysis of Oxaliplatin or Paclitaxel Salvage Chemotherapy.- Platinum Compounds in Lung Cancer: Current Status.- Is Lipoplatinum Monotherapy an Active Alternative in Second Line Treatment of Metastatic Non–Small Cell Lung Cancer? A Phase II Trial.- Combining Platinums in Gastric Cancer.- Oxaliplatin-Based Chemotherapy for Colon Cancer.- First-Line Systemic Chemotherapy with Folfoxiri Followed by Radical Surgical Resection of Metastases for the Treatment of Unresectable Metastatic Colorectal Cancer Patients.- Pre-operative Radio-Chemotherapy of Rectal Cancer: Toxicity and Preliminary Results with the Addition of Weekly Oxaliplatin.- The Role of Platins in Newly Diagnosed Endometrial Cancer.- Platinum Compounds: Key Ingredients in Ovarian Cancer Treatment and Strategies.- Intraperitoneal Chemotherapy: An Important Strategy in Ovarian Cancer Treatment.- Novel Strategies for Enhancingthe Efficacy of Intraperitoneal Chemotherapy for Patients with Ovarian Cancer.- Laparoscopically Assisted Heated Intra-Operative Intraperitoneal Chemotherapy (HIPEC): Technical Aspect and Pharmacokinetics Data.- Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity.- Peripheral Neurotoxicity of Platinum Compounds.- Platinum Drugs in Children with Cancer.- Optimising Carboplatin Dose using Patient Characteristics and Therapeutic Drug Monitoring.