Oxidative Stress and Biomaterials (eBook)

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation.

No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations.

In this embattled terrain, the most we can hope for from the biomaterials we design is a type of 'meso-compatibility,” a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.

• Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death
• Brings together the two fields of biomaterials and the biology of oxidative stress
• Provides approaches for the design of biomaterials with improved biocompatibility

Dr. Thomas Dziubla, Ph.D. is the Associate Gill Professor and Director of Graduate Studies in the Department of Chemical and Materials Engineering at the University of Kentucky. He received his B.S. and Ph.D in Chemical Engineering from Purdue University (1998) and Drexel University (2002), respectively. In 2002-2004, he was an NRSA postdoctoral fellow in the Institute for Environmental Medicine at the University of Pennsylvania's School of Medicine under the guidance of Dr. Vladimir Muzykantov, where he worked on the design of degradable polymeric nanocarriers for the delivery of antioxidants. His research group is interested in the design of new functional polymeric biomaterials, which can actively control local cellular oxidative stress for improved biomaterial integration and disease treatment. Dr. Dziubla is a member of Society for Biomaterials and American Institute of Chemical Engineers. He holds 8 patents, has authored over 50 peer reviewed publications and has started several companies that are currently commercializing technologies that have originated from his laboratory.

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Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "e;meso-compatibility,? a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility