Textbook of Diabetes 5e

Richard I.G. Holt, MA, MB BChir, PhD, FRCP, FHEA Professor in Diabetes & Endocrinology, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton, UK. Clive S. Cockram, MB BS, BSc, MD (Lond), FRCP, FRACP, FHKAM (Med) Emeritus Professor of Medicine, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China. Allan Flyvbjerg, MD, DMSc Professor of Clinical Endocrinology and Chair, Department of Endocrinology and Internal Medicine, The Medical Research Laboratories, Aarhus University Hospital - Aarhus University, Aarhus, Denmark. Barry J. Goldstein, MD, PhD, FACP, FACE Therapeutic Area Head, Diabetes and Obesity, Vice President, Clinical Research, Metabolism, Merck Research Laboratories, Rahway, NJ, USA.

List of Contributors, viii Preface to the Fifth Edition, xiv List of Abbreviations, xv About the Companion Website and Companion Digital Edition, xviii Part 1 Diabetes in its Historical and Social Context 1 The History of Diabetes Mellitus, 3 Robert B. Tattersall 2 Classification and Diagnosis of Diabetes, 23 Ambady Ramachandran, Chamukuttan Snehalatha, and Arun Nanditha 3 Epidemiology of Type 1 Diabetes, 29 Lars C. Stene and Jaakko Tuomilehto 4 Epidemiology of Type 2 Diabetes, 43 Ronald C.W. Ma and Peter C.Y. Tong 5 The Global Burden of Diabetes, 65 Mohammed K. Ali, Karla I. Galaviz, Mary Beth Weber, and K.M. Venkat Narayan Part 2 Normal Physiology 6 Islet Function and Insulin Secretion, 87 Peter M. Jones and Shanta J. Persaud 7 Glucagon in Islet and Metabolic Regulation, 103 Darleen Sandoval, Jenny Tong, and David D Alessio 8 Mechanism of Insulin Action, 114 Morris F. White 9 Control of Weight: How DoWe Get Fat?, 133 Arianne N. Sweeting and Ian D. Caterson Part 3 Pathogenesis of Diabetes 10 Autoimmune Type 1 Diabetes, 143 Shehab Alshiekh, Helena Elding Larsson, Sten-A. Ivarsson, and ?? Ake Lernmark 11 Other Disorders with Type 1 Phenotype, 154 Alice P.S. Kong, Elaine Y.K. Chow, and Juliana C.N. Chan 12 Abnormalities of Insulin Secretion and -Cell Defects in Type 2 Diabetes, 161 Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele 13 Insulin Resistance in Type 2 Diabetes, 174 Michael Roden, Kitt Petersen, and Gerald Shulman 14 Genetic Architecture of Type 2 Diabetes, 187 Rashmi B. Prasad and Leif Groop 15 Metabolic Disturbances in Diabetes, 205 Adrian Vella and Robert A. Rizza 16 Obesity and Diabetes, 215 Hans Hauner 17 The Microbiome and Diabetes, 229 Amanda J. Cox, Nicholas P.West, and AllanW. Cripps Part 4 Other Types of Diabetes 18 Monogenic Causes of Diabetes, 243 Shivani Misra and Andrew T. Hattersley 19 Drug-Induced Diabetes, 262 Charles D. Ponte and Devra K. Dang 20 Endocrine Disorders that Cause Diabetes, 272 Rachel E. Jennings and Neil A. Hanley 21 Pancreatic Diseases and Diabetes, 291 Ranjit Unnikrishnan and Viswanathan Mohan Part 5 Managing the Patient with Diabetes 22 Clinical Presentations of Diabetes, 305 Ee Lin Lim and Roy Taylor 23 The Aims of Diabetes Care, 314 Katharine D. Barnard and Richard I.G. Holt 24 Educating the Person with Diabetes, 326 Ingrid Willaing and Michael Vallis 25 Lifestyle Issues: Diet, 341 Nicola Guess 26 Lifestyle Issues: Exercise, 353 Mimi Z. Chen and Robert C. Andrews 27 Monitoring Diabetes, 374 Andrew Farmer 28 Drug Therapy: Special Considerations in Diabetes, 385 Bernard M.Y. Cheung and Ronald C.W. Ma Part 6 Treatment of Diabetes 29 Insulin and Insulin Treatment, 401 Stephen Gough and Parth Narendran 30 New Technologies for Glucose Monitoring and Insulin Administration, 414 David L. Horwitz and David C. Klonoff 31 Oral Glucose-Lowering Agents, 426 Clifford J. Bailey and Andrew J. Krentz 32 Non-Insulin Parenteral Therapies, 455 Tina Vilsboll, Mikkel Christensen, Tina Jorsal, and Filip K. Knop 33 How to Use Type 2 Diabetes Treatments in Clinical Practice: Combination Therapies, 471 Silvio E. Inzucchi and David R. Matthews 34 In-Hospital Treatment and Surgery in People with Diabetes, 493 Ketan Dhatariya and June James 35 Hypoglycemia in Diabetes, 513 Philip E. Cryer and Ana Maria Arbelaez 36 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State, 534 Niels Moller Part 7 Microvascular Complications in Diabetes 37 Pathogenesis of Microvascular Complications, 543 Allan Flyvbjerg 38 Diabetic Retinopathy, 554 Toke Bek 39 Diabetic Nephropathy, 566 Sally M. Marshall and Allan Flyvbjerg 40 Diabetic Peripheral and Autonomic Neuropathy, 580 Dan Ziegler Part 8 Macrovascular Complications in Diabetes 41 Pathogenesis of Macrovascular Complications in Diabetes, 611 Stephen P. Gray, Elyse Di Marco, Riccardo Candido, Mark E. Cooper, and Karin A.M. Jandeleit-Dahm 42 Cardiovascular Risk Factors: Hypertension, 629 Peter M. Nilsson 43 Diabetic Dyslipidemia and Risk of Cardiovascular Disease, 643 Adie Viljoen, Supriya Joshi, and Anthony S.Wierzbicki 44 Ischemic Heart Disease in Diabetes, 653 Christoph H. Saely, Kourosh Vathie, and Heinz Drexel 45 Congestive Heart Failure, 659 Anna Norhammar, Isabelle Johansson, Inga S. Thrainsdottir, and Lars Ryden 46 Cerebrovascular Disease, 673 Colum F. Amory and Jesse Weinberger 47 Peripheral Vascular Disease, 683 Henrik H. Sillesen Part 9 Other Complications of Diabetes 48 Foot Problems in People with Diabetes, 701 Andrew J.M. Boulton 49 Sexual Function in Men andWomen with Diabetes, 716 David Price 50 Gastrointestinal Manifestations of Diabetes, 731 Adil E. Bharucha and Michael Camilleri 51 Diabetes and Non-Alcoholic Fatty Liver Disease, 745 Shivakumar Chitturi and Geoffrey C. Farrell 52 The Skin in Diabetes, 759 Graham R. Sharpe and Paul D. Yesudian 53 Bone and Rheumatic Disorders in Diabetes, 773 Andrew Grey and Nicola Dalbeth 54 Diabetes and Cancer: Evidence for Risk, Methodology and Implications, 789 Ellena Badrick and Andrew G. Renehan 55 Diabetes and Infections, 799 Clive S. Cockram and Bonnie C.K.Wong Part 10 Psychosocial Aspects of Diabetes 56 Psychological Factors and Diabetes Mellitus, 821 Frans Pouwer and Jane Speight 57 Psychiatric Disorders and Diabetes, 840 Richard I.G. Holt and Leslie Citrome 58 Social Aspects of Diabetes, 859 Brian M. Frier and Mark W.J. Strachan Part 11 Diabetes in Special Groups 59 Diabetes in Childhood, 879 Shideh Majidi, Christine M. Chan, and Marian Rewers 60 Adolescence and Emerging Adulthood: Diabetes in Transition, 896 Rebecca K. Snelgrove, Dayna E. McGill, and Lori M.B. Laffel 61 Diabetes in Pregnancy, 909 Tim Cundy 62 Diabetes in Old Age, 939 Ahmed H. Abdelhafiz and Alan J. Sinclair 63 Diabetes at the End of Life, 953 June James, Jean MacLeod, and Robert Gregory Part 12 Delivery and Organization of Diabetes Care 64 The Role of the Multidisciplinary Team Across Primary and Secondary Care, 963 Samuel I. Seidu, Kamlesh Khunti, and Melanie J. Davies 65 Models of Diabetes Care Across Different Resource Settings, 973 Naomi S. Levitt, Sam Surka, Andrew Farmer, and Bob Mash Part 13 Future Directions 66 Future Drug Treatments for Type 1 Diabetes, 987 Jennifer L. Sherr, Eda Cengiz, Michelle A. Van Name, Stuart A.Weinzimer, and William V. Tamborlane 67 Future Drug Treatments for Type 2 Diabetes, 1000 Clifford J. Bailey 68 Stem Cell Therapy in Diabetes, 1012 Angelo Avogaro and Gian Paolo Fadini 69 Islet Transplantation, 1017 Angela Koh, Peter E. Senior, and A.M. James Shapiro 70 Gene Therapy for Diabetes, 1029 Virginia Haurigot, Veronica Jimenez, and Fatima Bosch 71 Future Models of Diabetes Care, 1038 Sanjeev N. Mehta and Robert A. Gabbay Index, 1049