Childhood Acute Lymphoblastic Leukemia

Professor Ajay Vora is honorary professor of paediatric haematology at University of Sheffield and consultant paediatric haematologist at Sheffield Children's Hospital. His daily practice involves the care of children with a variety of malignant and non-malignant blood disorders. He has a special interest in childhood leukaemia and cord blood transplantation. He is chair of the UK NCRI childhood leukaemia sub-group and I-BFM ALL committee. He is chief investigator of childhood and infant ALL clinical trials and is involved with several research projects in this area. He is programme director of the Trent Regional Paediatric Haemopoeitic Stem Cell transplant service.

Epidemiology including genetic predisposition.- Clinical Features.- Diagnostic flow cytometry and immunophenotypic classification.- Cytogenetics.- Molecular genetics.- Pharmacology including pharmacokinetics, pharmacodynamics and pharmacogenetics.- Minimal Residual Disease.- Treatment - first line.- Treatment - relapse.- Treatment - new drugs.- Treatment - immune based approaches.- Cellular therapy.- Supportive care.- Developing world perspective.

"The purpose is to provide an in-depth look at the complex disease of childhood ALL. ... a concise resource such as this can be used by many medical professionals such as physicians, advanced practitioners, medical students, and nurses in pediatric oncology. ... The information is concise and detailed, which makes it a good resource for expert or advanced practitioners in oncology ... ." (Lacie D. Filkins, Doody's Book Reviews, July, 2017)