Mechanisms of Cell Injury

This volume examines the current status of scientific knowledge concerning mechanisms of chemical-induced cell injury/cell death and the implications of these processes for human health. Topics covered include the role of metabolism in mediating toxicity, molecular mechanisms of cell injury/cell death, approaches for estimating human exposure to toxic chemicals, and the known roles of toxic chemicals in human target organ toxicity. The information presented hence provides the reader with an integrated assessment of this increasingly important problem area ranging from the most fundamental aspects of cell biology to the human health consequences of exposure to toxic chemicals. Current gaps in knowledge are delineated and research recommendations are given for each of the major topic areas. This volume should be of value not only to those concerned with basic biological research but also to persons involved in making societal decisions concerning the public health consequences of toxic chemical exposure.