Myelodysplastic/Myeloproliferative Neoplasms

Srdan Verstovsek, MD, PhD, Professor of Medicine, Director, Hanns A. Pielenz Clinical Research Center for Myeloproliferative Neoplasms, University of Texas MD Anderson Cancer Center, Houston, TX, USA Hans Michael Kvasnicka, MD, Assistant Professor at the Institute of Pathology, University of Frankfurt, Frankfurt, GermanyJuergen Thiele, MD, Associate Professor for Pathology, Institute of Pathology, University of Cologne, Germany

Problems and pitfalls regarding differentiation of MDS, MDS/MPN, and MPN. Overview of MDS. Diagnostic problems of initial MDS. MDS with unilineage and multilineage dysplasia. MDS with fibrosis vs. early primary myelofibrosis (PMF). MDS with 5q- vs. ET. Overview of MDS/MPN. Diagnostic problems of MDS/MPN and differentiation from MPN or MDS. CMML vs. Atypical CML. RARS-T vs. PMF, PV, ET. MDS/MPN,U vs. MPN-U. Acute panmyelosis with myelofibrosis vs. PMF, post PV and post ET MF. Overview of MPN. Diagnostic problems of initial MPN stages. ET vs. prefibrotic/early PMF and masked PV. PV with (initial) fibrosis vs. post PV-MF. PMF vs. post PV and post ET-MF. Progression in MPN – MDS-like and blast phase.