The Bipolar Book

Aysegül Yildiz, MD Professor of Psychiatry Dokuz Eylül University Izmir, Turkey; Pedro Ruiz, MD Clinical Professor of Psychiatry and Behavioral Sciences University of Texas Medical School at Houston Houston, TX, USA; Charles B. Nemeroff, MD, PhD Leonard M. Miller Professor & Chairman Department of Psychiatry University of Miami - Miller School of Medicine Miami, FL, USA

Section I: Clinical Presentation

Chapter 1. From the Era of Aretaeus to the Millennium: History of Bipolar Disorder Over 2000 Years
Chapter 2. Update on Epidemiology, Risk Factors and Correlates of Bipolar Spectrum Disorder
Chapter 3. Clinical Presentation & DSM-based Diagnostic Assessment
Chapter 4. Differential Diagnosis & Bipolar Spectrum Disorders
Chapter 5. Diagnosing Bipolar Disorder in Children and Adolescents
Chapter 6. Effect of Public Awareness & Stigmatization on Accurate & Timely Diagnosis of Bipolar Disorder

Section II: Insights on Pathophysiology & Future Treatments

Part I: Molecular Biology
Chapter 7. Oxidative Damage & Its Treatment Impact
Chapter 8. The Role of Signal Transduction Systems in the Pathophysiology and Treatment of Bipolar Disorder
Chapter 9. Cellular Resilience and Neurodegeneration and Their Impact on the Treatment of Bipolar Disorder
Chapter 10. Immune Mechanisms and Inflammation & Their Treatment Impact
Chapter 11. Circadian Rhythms and Sleep & Its Treatment Impact
Chapter 12. HPA & HPT Axis & Their Treatment Impact
Chapter 13. Translating Bio-markers and Bio-molecular Treatments to Clinical Practice: Assessment of Hypothesis Driven Clinical Trial Data

Part II: Genetic
Chapter 14. Bipolar Family & Bipolar Offspring Studies: Any Clues for Prevention or Early Intervention
Chapter 15. The Emerging Genetics of Bipolar Disorder

Part III: Cognition

Chapter 16: Cognitive Impairments and Everyday Disability in Bipolar Illness

Part IV: Neuroimaging

Chapter 17. Structural & Functional Magnetic Resonance Imaging Findings & Their Treatment Impact
Chapter 18. Magnetic Resonance Spectroscopy Findings & Their Treatment Impact
Chapter 19. PET Scan Findings & Their Treatment Impact

Part V: Postmortem studies

Chapter 20. Postmortem Findings in Bipolar Disorder & Their Treatment Impact

Section III: Current Treatments

Part I: Pharmacological Treatments

Chapter 21. Treatment of Mania & Mixed States
Chapter 22. Pharmacological Treatment of Acute Bipolar Depression
Chapter 23. Maintenance Treatments in Bipolar Disorder
Chapter 24. Importance of Early Intervention in Bipolar Disorder
Chapter 25. Alternative and Complementary Treatments

Part II: Somatic Non-Pharmacological Treatments

Chapter 26. ECT and Bipolar Disorder
Chapter 27. Neuromodulative Treatments for Bipolar Disorder: Repetitive Transcranial Magnetic Stimulation, Vagus Nerve Stimulation and Deep Brain Stimulation

Part III: Adverse treatment effects

Chapter 28. Management of Metabolic and Endocrinological Effects
Chapter 29. Neurological, Cognitive and Neuroprotective Effects of Treatments in Bipolar Disorder
Chapter 30. Treatment Induced Mood Instability-TEAs and Cycle Acceleration

Part IV: Psychotherapy

Chapter 31. Cognitive Behavioral Therapy and Psychoeducation
Chapter 32. Family Focused Therapy, Interpersonal and Social Rhythm Therapy & Dialectical Behavioral Therapy

Part V: Comorbidity

Chapter 33. Management of Comorbid Axis-I Psychiatric Disorders
Chapter 34. Management of Cyclothymia and Comorbid Axis-II Psychiatric Disorders
Chapter 35. Management of Comorbid Substance or Alcohol Abuse
Chapter 36. Management of Comorbid Medical Problems

Part VI: Suicidality

Chapter 37. Clinical Management of Suicide Risk

Part VII: Pregnancy & Lactation

Chapter 38. Management of Bipolar Disorder During Pregnancy and Lactation

Part VIII: Children & Adolescents

Chapter 39. Management of Bipolar Disorder in Children and Adolescents

Part IX: Elderly

Chapter 40. Bipolar Disorder in the Elderly

Section IV: Future Research

Chapter 41. Placebo Response in Clinical Trials for Bipolar Disorder: Potential Causes, Potential Solutions
Chapter 42. Strategies for Improving Randomized Trial Evidence in Treatment of Bipolar Disorder
Chapter 43. Challenges in Designing Reliable and Feasible Treatment Trials for Bipolar Disorder
Chapter 44. Sequential Multiple Assignment Randomized Trials
Chapter 45. Traditional and Novel Research Synthesis Approaches to Support Evidence-based Treatment Decisions