The Sentinel Lymph Node Concept

General Part.- Definition of the Sentinel Lymph Node and Basic Principles of Detection.- Main Techniques of Sentinel Lymph Node Labeling.- Different Aspects Dependent on Type and Localization of the Primary.- Basic Strategies in Sentinel Node Detection and Exclusion or Verification of Cancer Metastasis into the Regional Node(s).- Positron Emission Tomography: Significance for Preoperative N-Staging.- Detection and Radiological Imaging of SLN.- Lymphatic Drainage to the SLN.- Specific Developments in Sentinel Node Labeling Using 99mTc-Colloids.- Experience with and Suggestions for Cancer of Different Types and in Different Sites.- General Techniques in Surgical Investigations.- Radiation-Detecting Systems.- Quality Criteria of Gamma Probes: Requirements and Future Developments.- Statistical Evaluation in Detection of the SLN(s).- Are the Technical Conditions for SLN Detection Satisfactory?.- Breast Cancer Diagnosis Based on Histopathology and/or Cytopathology Before Sentinel Lymph Node Labeling.- Success of Stereotactic Fine-Needle Aspiration Cytology Depending on Quality of Sampling.- Use of a Newly Developed Ultrarapid Immunohistochemical Method to Improve Security in Sentinel Node Investigation and Timing in Interdisciplinary Cooperation.- "Micrometastasis" Versus "Microinvolvement".- Preoperative Axillary Lymph Node Diagnosis Using Ultrasmall Particles of Iron Oxide Combined with MRT.- New Strategies and Devices for Combined Radiological and Histological Cancer Diagnosis - Exclusion or Confirmation.- Special Part The Sentinel Node Concept Related to Main Tumor Types and Subtypes: Applicability in Daily Routine Work.- Breast Cancer.- Thyroid Cancer.- Cancers of the Face, Nose, Pharynx, and Oral Cavity.- Lung Cancer.- Malignant Melanoma.- Esophageal andGastrointestinal Cancer.- SLN Staging in Carcinoids and Neuroendocrine Tumors.- The Sentinel Node Concept in Cancers of the Female Genitalia.- Cancers of the Male Genitalia.- Prostate Cancer: an Overview.- Cancers of the Urinary Tract.- Closing Remarks.- Therapy Regimens Used in Adjuvant and Neoadjuvant Treatment of the Discussed Tumor Types.

From the reviews:

Br J Surg (2005) 92 (4) p. 495: "This is a book not only for surgeons but also for other specialists for whom regional tumour growth has implications for treatment. The whole spectrum...is fully covered in 33 chapters. I can wholeheartedly recommend this book to those whose practice requires the diagnosis and treatment of locoregional malignant disease."

RAD Maganzine, Sept. 2005: " I was surprised by the extent to which sentinel lymph node biopsy has been extended from melanoma and breast cancers to head and neck, lung, upper GI tract, gynaecological, penile, testicular and urinary tract, including prostate cancers....a beautifully produced book with magnifcent colour pictures and drawings.

"Anyone involved in sentinel lymph node biopsies would be well advised to obtain a copy of this book. A balanced viewpoint is given about the value of this concept and how the indications vary throughout the medical world. ... a beautifully produced book with magnificent colour pictures and drawings. I would thoroughly recommend this book to anyone interested in sentinel lymph nodes ... ." (Dr. P Dyson, RAD Magazine, September, 2005)

"It deals with the sentinel node concept even in tumours in which this node receives little attention in everyday practice. ... This is a book not only for surgeons but also for other specialists for whom regional tumour growth has implications for treatment. ... Its illustrations ... are of high quality and the references are up to date. ... I can whole-heartedly recommend this book to those whose practice requires the diagnosis and treatment of locoregional malignant disease." (T. Wobbes, The British Journal of Surgery, Vol. 92(4), 2005)

"This book focuses on the sentinel node (SN) concept. ... This book is well written and easily understandable for nuclear medicine physicians, surgeons, oncologists, physicists and all the other different specialists interested in SN detection. The textcontains comprehensive information on this field ... . In conclusion, this book can be considered a good piece of work that is to be recommended to all readers who would like to have an exhaustive and up-to-date manual on this very important nuclear medicine procedure." (E. Bombardieri, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 33 (1), 2006)