Disorders of Hemostasis and Thrombosis: A Clinical Guide

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Section I: Hemostasis and Thrombosis--General Considerations.Physiology of Hemostasis and Thrombosis.Laboratory Measurments of Hemostasis and Thrombosis.Normal Values for the Hemostatic System.Section II: Hemorrhagic Disorders.Screening Tests of Hemostasis.Evaluation of Bleeding Tendency in Outpatient Child and Adult.Evaluation of Bleeding Tendency in the Hospitalized Patient.Evaluation of Bleeding in the Newborn.Thrombocytopenias.Immune Thrombocytopenia.Hereditary Platelet Function Defects.Acquired Platelet Function Disorders.Hereditary von Willebrand Disease.Acquired von Willebrand Disease.Hemophilia A (Factor VII Deficiency).Hemophilia B (Factor IX Deficiency).Hereditary Factor XI Deficiency.Contact Factor Deficiencies.Prothrombin, Factor V, Factor VII, Factor X, and Combined Factor Deficiencies.Abnormalities of Fibrinogen.Factor XIII, 2-Antiplasmin and Plasminogen Activator Inhibitor-1 Deficiencies.Acquired Coagulation Factor Inhibitors.Bleeding Associated with Vascular Disorders.Vitamin K Deficiency.Liver Diseases.Disseminated Intravascular Coagulation.Systemic Fibrinolysis.Massive Blood Transfusion.Hemostatic Defects in Renal Disease and Renal Failure.Thrombotic Thrombocytopenia Purpura and the Hemolytic Uremic Syndrome.Bleeding and Cancer.Hemorrhagic Disorders in Obstetrics.Bleeding Related to Congenital Heart Disease and Cardiac Surgery.Lymphoproliferrative Disorders.Bleeding in the Myeloid Disorders--Acute Leukemia, Myelodysplasia, and Myeloproliferative Disease.Toxic Coagulopathies.Section III: Thrombotic Disorders.The Infant and Child with Thrombosis.The Adult with Thrombosis.Deep Venous Thrombosis and Pulmonary Embolism.Antithrombin III Deficiency.Protein C Deficiency.Protein S Deficiency.Fibrinolytic Defects and Thrombosis.Antiphospholipid Antibodies.Myeloproliferative Disorders and Paroxysmal Nocturnal Hemoglobinuria.Other Potential Causes of Thrombosis.Heparin Associated Thrombocytopenia.Thrombosis and Cancer.Atherosclerosis and Thrombosis.Vascular Disorders Associated with Thrombosis.Cardiac Disease and Thrombosis.Cerebrovascular Disease and Thrombosis.Thrombosis in Pregnancy.Section IV: Treatment Modalities.Platelet Transfusions.Fresh Frozen Plasma.Cryoprecipitate.Coagulation Factor Concentrates.Apheresis and Exchange Transfusion.Intravenous Immunoglobulin.Desmopressin (DDAVP).Antifibrinolytic Agents.Heparins.Oral Anticoagulants.Thrombolytic Agents.Antiplatelet Agents.Other Measures for Treatment or Prevention of Thrombosis.