The Cutaneous Lymphoid Proliferations (eBook)
John Wiley & Sons (Verlag)
978-1-118-77652-0 (ISBN)
A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease.
- Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin
- Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing the immunohistochemica nd molecular aspects of lymphoid neoplasia.
- Each chapter contains an extensive array of 'clinical vignettes' clearly showing the application of principles and treatment techniques discussed in the chapter
- Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the interplay between the immune system in the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail.
- Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition
Cynthia M. Magro MD
Professor of Pathology and Laboratory Medicine
Department of Pathology, Cornell University
Weill Cornell Medicine
New York, NY, USA
A. Neil Crowson MD
Clinical Professor of Dermatology, Pathology, and Surgery
Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory
President of Pathology Laboratory Associates
Tulsa, OK, USA
Martin C. Mihm MD
Clinical Professor of Pathology and Dermatology, Harvard Medical School
Director of Melanoma Program, Dermatology, Brigham and Women's Hospital
Co-Director of Melanoma Program, Dana-Farber and Brigham and Women's Cancer Center
Director, Mihm Cutaneous Pathology Consultative Service
Brigham and Women's Hospital
Boston, MA, USA
A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease. Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing the immunohistochemica nd molecular aspects of lymphoid neoplasia. Each chapter contains an extensive array of clinical vignettes clearly showing the application of principles and treatment techniques discussed in the chapter Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the interplay between the immune system in the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail. Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition
Cynthia M. Magro MD Professor of Pathology and Laboratory Medicine Department of Pathology, Cornell University Weill Cornell Medicine New York, NY, USA A. Neil Crowson MD Clinical Professor of Dermatology, Pathology, and Surgery Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory President of Pathology Laboratory Associates Tulsa, OK, USA Martin C. Mihm MD Clinical Professor of Pathology and Dermatology, Harvard Medical School Director of Melanoma Program, Dermatology, Brigham and Women's Hospital Co-Director of Melanoma Program, Dana-Farber and Brigham and Women's Cancer Center Director, Mihm Cutaneous Pathology Consultative Service Brigham and Women's Hospital Boston, MA, USA
The Cutaneous Lymphoid Proliferations 3
Contents 7
Acknowledgments 10
1 Introduction to the Classification of Lymphoma 11
Kiel Lukes–Collins, and Working Formulation classifications 11
WHO, REAL, EORTC, and the Combined WHO/EORTC classifications 12
Summary 17
References 18
Appendix: Definitions of key terms and techniques 19
2 The Therapy of Cutaneous T Cell Lymphoma 24
Introduction 24
Diagnostic work-up and staging procedures 24
CTCL therapies 25
Skin-directed therapies 25
Goals of therapy in advanced-stage CTCL 26
Extracorporeal photopheresis (ECP) 27
Interferons 27
Retinoids 27
Immunotoxins 28
Monoclonal antibodies 28
Histone deacetylase inhibitors (HDACi) 29
Antibody drug conjugates (ADC) 29
Cytotoxic chemotherapy 29
Investigational therapies 30
TLR agonists and cytokines 30
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) 30
References 31
3 Molecular Analysis in Cutaneous Lymphoid Proliferation 33
Introduction 33
Immunoglobulin and T cell receptor structure 33
IgH 33
TCR 34
PCR design for determination of clonality 34
Detection of PCR products for clonality 34
Evaluation of results 35
The value and utility of molecular diagnostics in primary cutaneous lymphomas 36
Limitations of clonality assessment by PCR 37
Case vignettes 39
Case vignette 1 39
Case vignette 2 41
Case vignette 3 42
Case vignette 4 43
Case vignette 5 44
Case vignette 6 45
References 46
4 Benign Lymphocytic Infiltrates 47
Introduction 47
Spongiotic and eczematous dermatitis 47
Allergic contact dermatitis 47
Pityriasis rosea 49
Pityriasis rosea-like drug reaction 50
Other spongiotic/eczematous tissue reactions 50
Photoallergic reactions 50
Other causes of subacute eczematous dermatitis 50
Nummular eczema 50
Small plaque parapsoriasis 51
Pruritic urticarial plaques and papules of pregnancy 51
Superficial erythema annulare centrifugum 52
Interface dermatitis: cell-poor vacuolar interface dermatitis 52
Erythema multiforme 52
Gianotti–Crosti syndrome (papular acrodermatitis of childhood) 54
Acute graft-versus-host disease 54
Morbiliform viral exanthem and morbiliform drug eruption 55
Collagen vascular disease compatible with antibody-dependent cellular immunity and/or antiendothelial-cell antibodies 55
Interface dermatitis: lichenoid pattern 56
Lichen planus 56
Lichen planus-like eruptions of hepatobiliary disease 58
Lichen planus-like eruptions of secondary syphilis 58
Lichenoid drug reactions 58
Lichenoid connective tissue disease syndromes 58
Lichenoid (“chronic”) graft-versus-host disease 60
Diffuse and nodular lymphocytic dermal infiltrates without atypia 61
Polymorphous light eruption as the prototypic type IV immune reaction 61
Other dermal perivascular lymphocytic infiltrates 62
Gyrate erythemas 63
Diffuse and nodular lymphocytic infiltrates associated with autoimmune disease 63
Nonscarring discoid lupus erythematosus/tumid lupus erythematosus 63
Morphea 64
Jessner’s lymphocytic infiltrate of the skin 66
References 67
5 Reactive Lymphomatoid Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma 69
Lymphomatoid drug eruptions 69
Clinical features 69
Histopathology 70
Phenotypic studies 71
Molecular profile of lymphomatoid drug eruptions 71
Pathogenetic basis of lymphomatoid drug reactions 72
Reactive lymphomatoid lesions encountered in lesions of collagen vascular disease 73
Lymphomatoid lupus erythematosus 73
Pathogenesis of lymphomatoid tissue response in collagen vascular disease 73
Lupus erythematosus profundus 73
Lymphomatoid lichen sclerosus 74
Viral-associated lymphomatoid dermatitis 75
Jessner’s lymphocytic infiltrate of skin 75
Lymphocytoma cutis 75
CLIPPERS syndrome with cutaneous involvement 76
Primary cutaneous plasmacytosis 76
Angiomatous Variants of Pseudolymphoma 77
Acral pseudolymphomatous angiokeratomas of children (APA CHE) 77
T-cell-rich angiomatoid polypoid pseudolymphoma of the skin 77
Angiolymphoid hyperplasia with eosinophilia and Kimura’s disease 77
Conclusion 78
Case vignettes 79
Case vignette 1 79
Case vignette 2 80
Case vignette 3 81
Case vignette 4 82
Case vignette 5 84
Case vignette 6 85
Case vignette 7 86
Case vignette 8 87
Case vignette 9 90
Case vignette 10 91
Case vignette 11 92
Case vignette 12 93
Case vignette 13 94
Case vignette 14 95
References 96
6 Precursor Lesions of Cutaneous T Cell Lymphoma 99
Cutaneous T cell lymphoid dyscrasia 99
Large plaque parapsoriasis 100
Light microscopic findings 100
Differential diagnosis 101
Hypopigmented interface T cell dyscrasia: a unique indolent T cell dyscrasia 101
Light microscopic findings 102
Phenotypic studies 102
Molecular studies 102
Pigmented purpuric dermatosis (PPD) 102
Light microscopic findings 104
Phenotypic studies 104
Molecular studies 104
Pityriasis lichenoides 104
Light microscopy 105
Phenotypic studies 105
Idiopathic erythroderma (pre-Sézary) 106
Light microscopic findings 106
Phenotypic and molecular studies 106
Syringolymphoid hyperplasia with alopecia 106
Light microscopic findings 107
Phenotypic studies 107
Differential diagnosis 107
Molecular studies 107
Folliculotropic T cell lymphocytosis/pilotropic T cell dyscrasia 107
Light microscopic findings 107
Phenotypic studies 108
Differential diagnosis 108
Idiopathic follicular mucinosis/alopecia mucinosa 108
Light microscopic findings 109
Phenotypic studies 109
Molecular studies 109
Keratoderma-like T cell dyscrasia 109
Light microscopic findings 109
Phenotypic studies 109
Pathogenesis 110
Atypical lymphocytic lobular panniculitis 110
Light microscopic findings 111
Phenotypic studies 111
Molecular studies 111
Case vignettes 112
Case vignette 1 112
Case vignette 2 115
Case vignette 3 119
Case vignette 4 121
Case vignette 5 123
Case vignette 6 125
Case vignette 7 127
Case vignette 8 128
Additional molecular and cytogenetic studies 129
References 142
7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin 144
Marginal zone lymphoma 144
Clinical features 144
Pathology 145
Phenotype 146
Molecular studies 147
Pathogenesis 148
Cytogenetic abnormalities and oncogenes 148
Differential diagnosis 149
Blastic marginal zone lymphoma 150
Light microscopic findings 150
Phenotypic profile 150
Cytogenetic profile 150
Epidermotropic marginal zone lymphoma 150
Castleman disease 151
Light microscopic findings 151
Phenotyping 152
Pathogenesis 152
Epidemiology 152
Differential diagnosis 152
Primary cutaneous plasmacytoma 152
Light microscopic findings 153
Phenotyping 153
Molecular studies 153
Pathogenesis 153
Differential diagnosis 153
Primary cutaneous light chain associated cutaneous amyloidosis 154
Case vignettes 155
Case vignette 1 155
Case vignette 2 158
Case vignette 3 162
Case vignette 4 164
Case vignette 5 166
Case vignette 6 168
Case vignette 7 169
Case vignette 8 170
Case vignette 9 171
Case vignette 10 174
References 176
8 Primary Cutaneous Follicle Center Cell Lymphoma 179
Clinical features 179
Pathology 179
Phenotypic profile 181
Molecular studies 182
Pathogenesis 182
Cytogenetics 182
Case vignettes 184
Case vignette 1 184
Case vignette 2 186
Case vignette 3 189
Case vignette 4 192
Additional molecular and cytogenetic study 195
References 196
9 Primary Cutaneous Diffuse Large B-Cell Lymphoma Including the Leg Type and Precursor B Cell Lymphoblastic Lymphoma 197
Primary cutaneous diffuse large B cell lymphoma 197
Overview 197
Brief synopsis regarding the various forms of mature germinal center and post germinal center diffuse large B cell lymphoma of the skin 202
Leg-type diffuse large B cell lymphoma 202
Primary cutaneous follicle center lymphoma 203
CD30+ large B cell lymphoma 203
Blastic marginal zone lymphoma 204
Cutaneous precursor B cell lymphoblastic lymphoma/lymphoblastic leukemia (precursor B cell acute lymphoblastic leukemia) 205
Systemic diffuse large B cell lymphomas with a propensity to involve the skin 207
Double-hit lymphoma 207
Burkitt’s Lymphoma 208
Granulocytic sarcoma 208
Case vignettes 210
Case vignette 1 210
Case vignette 2 213
Case vignette 3 216
Case vignette 4 218
Additional light microscopic, phenotypic, molecular, cytogenetic studies 220
Cutaneous B cell lymphoblastic lymphoma 220
References 225
10 Intravascular Lymphoma 228
Clinical features 228
Light microscopic findings 229
Phenotypic profile 229
Molecular and cytogenetic studies 229
Pathogenesis 229
Differential diagnosis 229
Intravascular anaplastic large cell lymphoma 229
Benign intravascular proliferations of histiocytes and reactive T cells 230
Case vignettes 231
Case vignette 1 231
Case vignette 2 233
References 234
11 Cutaneous Mantle Cell Lymphoma 235
Clinical features 235
Light microscopic findings 235
Phenotypic profile 236
Molecular studies 237
Cytogenetic profile 237
Pathogenesis 237
Case vignettes 239
Case vignette 1 239
Case vignette 2 241
Case vignette 3 242
Additional molecular and cytogenetic studies 243
References 244
12 Mycosis Fungoides and Sézary Syndrome 246
Definition 246
Mycosis fungoides 246
Historical perspective 246
Demographics 246
Clinical presentation 246
Clinical variants 249
Papuloerythroderma 249
Mycosis fungoides in childhood 250
Adnexotropic mycosis fungoides including follicular mycosis fungoides 250
Woringer–Kolopp disease (pagetoid reticulosis) 251
Solitary mycosis fungoides of the non-Woringer–Kolopp subtype 251
Vesicular mycosis fungoides 251
Granulomatous mycosis fungoides including granulomatous slack skin 252
Interstitial mycosis fungoides 252
Sézary syndrome and erythrodermic mycosis fungoides 253
A consideration regarding the 2007 revised classification for mycosis fungoides and Sézary syndrome 255
Large cell transformation of mycosis fungoides 261
Extracutaneous involvement in mycosis fungoides 264
Phenotypic profile 264
Molecular profile 266
Cytogenetics 267
Pathogenesis 267
Case vignettes 269
Case vignette 1 269
Additional molecular and cytogenetic studies 271
Case vignette 2 276
Case vignette 3 278
References 281
13 CD30-Positive Lymphoproliferative Disorders Including Lymphomatoid Papulosis, Borderline CD30-Positive Lymphoproliferative Disease, Anaplastic Large Cell Lymphoma, and T-Cell-Rich CD30-Positive Large B Cell Lymphoma 284
Introduction 284
Lymphomatoid papulosis 284
Clinical features 284
Pathology of classic type A and type B LYP 286
Phenotypic and molecular studies 287
Cytogenetics 287
CD8+ lymphomatoid papulosis, including the type D variant 288
Light microscopic findings 288
Histogenesis 288
Differential diagnosis 288
Type E lymphomatoid papulosis (Case vignette 15) 288
Histology 288
Phenotypic studies 289
Borderline CD30-positive lymphoproliferative disorders (type C LYP) (Case vignette 9) 289
Light microscopic findings 289
Phenotypic studies 289
Treatment 289
Lymphomatoid papulosis with a rearrangement of chromosome 6p25.3 289
Light microscopic findings 289
Phenotypic studies 289
Cytogenetics 289
Differential diagnosis 290
Cutaneous anaplastic large cell lymphoma 290
Light microscopic findings 291
Small cell ALCL 292
Additional unusual histologic variants of anaplastic large cell lymphoma 292
Breast-implant-associated anaplastic large cell lymphoma 292
Intravascular anaplastic large cell lymphoma 292
Sarcomatoid anaplastic large cell lymphoma (Case vignette 14) 293
Phenotypic studies 293
Cytogenetics 294
Pathogenesis 294
CD30-positive large B cell lymphoma 295
Light microscopic findings 295
Phenotypic studies 295
Differential diagnosis 295
Case vignettes 296
Case vignette 1 296
Case vignette 2 297
Case vignette 3 298
Case vignette 4 299
Case vignette 5 300
Case vignette 6 302
Case vignette 7 303
Case vignette 8 304
Case vignette 9 306
Case vignette 10 307
Case vignette 11 308
Case vignette 12 309
Additional light microscopic, molecular and cytogenetic studies 310
Case vignette 13 313
Case vignette 14 315
Case vignette 15 (Figure 13.56a–13.56e) 317
References 319
14 CD4+ Peripheral T Cell Lymphoma, Not Otherwise Specified, Including Primary Cutaneous Cd4+ Small/Medium-Sized Pleomorphic T Cell Lymphoma 322
Introduction 322
Primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma 322
CD30-negative large cell T cell lymphoma 323
Cutaneous follicular helper T cell lymphoma 324
Overview of overall prognosis of primary cutaneous peripheral T cell lymphoma, unspecified, 325
Pathology/light microscopic findings 325
Phenotypic profile 326
Molecular profile 328
Cytogenetics 328
Pathogenesis of peripheral T cell lymphoma, NOS 328
Differential diagnosis 328
Evolution of the nomenclature of primary cutaneous CD4+ small/medium-sized pleomorphic T cell lymphoma 329
Case vignettes 330
Case vignette 1 330
Case vignette 2 332
Case vignette 3 334
Case vignette 4 336
Case vignette 5 337
Case vignette 6 338
Case vignette 7 339
Additional molecular and cytogenetic study 342
References 343
15 Subcutaneous Panniculitis-Like T Cell Lymphoma 344
Clinical features 344
Morphology 346
Phenotype 347
Molecular studies 347
Differential diagnosis 347
Case vignettes 350
Case vignette 1 350
Case vignette 2 353
Case vignette 3 355
Additional images depicting salient light microscopic and phenotypic features of subcutaneous panniculitis-like T cell lymphoma 357
References 359
16 CD8 T Cell Lymphoproliferative Disease of the Skin 361
Overview 361
Introduction 361
Classification of primary CD8+ cutaneous T cell lymphomas 362
Histomorphology of primary cutaneous CD8+ T cell lymphoma: primary cutaneous aggressive epidermotropic CD8+ cytotoxic T cell lymphoma, and CD8+ variants of peripheral T cell lymphoma, NOS, including primary cutaneous CD8+ granulomatous T cell lymphoma 363
Phenotype 364
CD8 variant of lymphomatoid papulosis and other related CD30-positive T cell lymphoproliferative disorders of CD8 subtype 364
Light microscopic findings 364
Indolent CD8 positive lymphoid proliferation of the face and other body sites including acral surfaces 365
Light microscopic findings 365
Phenotypic studies 365
Clonality studies 365
Treatment 365
Differential diagnosis 365
CD8 prolymphocytic leukemia 365
Histopathology 365
CD8 pseudolymphoma related to underlying HIV disease 366
Light microscopic findings 366
Phenotypic studies 366
Molecular studies 366
Drug-associated CD8+ pseudolymphoma 366
Actinic reticuloid as a unique form of CD8+ pseudolymphoma 366
Light microscopic findings 366
Phenotypic studies 366
Molecular studies 366
Case vignettes 367
Case vignette 1 367
Case vignette 2 370
Case vignette 3 373
Case vignette 4 374
Case vignette 5 375
Case vignette 6 376
Case vignette 7 378
Case vignette 8 380
Case vignette 9 381
Case vignette 10 382
Case vignette 11 384
References 385
17 Nasal and Related Extranodal Natural Killer Cell/T Cell Lymphomas and Blastic Plasmacytoid Dendritic Cell Neoplasm 387
Introduction 387
Biology of NK and NK-like T cells 387
NK/T-cell lymphoma 389
Nasal NK/T cell lymphoma 389
Nasal type NK/T cell lymphoma 390
Aggressive NK cell lymphoma 390
Pathology 390
Phenotypic studies 391
Molecular studies 392
Cytogenetics 392
Differential diagnosis 392
Role of Epstein–Barr virus in the evolution of NK/T cell lymphomas 392
Blastic plasmacytoid dendritic cell neoplasm 392
Light microscopic findings 393
Phenotypic studies 393
Molecular studies 393
CD56-positive ? ? lymphoma involving the subcutaneous fat 393
Chronic granular lymphocytosis/large granular cell leukemia 394
Natural killer-like CD4+ T cell lymphoma 394
Clinical features 394
Light microscopic findings 394
Phenotypic studies 395
Molecular studies 395
Cell of origin 395
EBV-associated NK/T cell lymphomas of the elderly 395
Hydroa vaccineforme (HV)-like lymphoma 395
Light microscopic findings 396
Phenotypic studies 396
Cutaneous intravascular NK T cell lymphoma 396
Case vignettes 397
Case vignette 1 397
Case vignette 2 400
Case vignette 3 401
Case vignette 4 403
Case vignette 5 405
Case vignette 6 407
Case vignette 7 409
References 411
18 Primary Cutaneous ? ? T Cell Lymphoma 414
Introduction 414
Clinical features 414
Light microscopic findings 417
Phenotypic studies 417
Ultrastructural analysis 418
Molecular and cytogenetic studies 418
Differential diagnosis 418
Case vignettes 419
Case vignette 1 419
Case vignette 2 420
Additional supplemental figures 421
References 424
19 Epstein–Barr Virus-Associated Lymphoproliferative Disease 425
Introduction 425
Hydroa vacciniforme-like EBV-associated T cell lymphoproliferative disease/mosquito bite hypersensitivity 426
Clinical features 426
Putative pathogenesis of mosquito bite hypersensitivity 426
Epstein–Barr-virus-associated B cell lymphoproliferative disease in the setting of iatrogenic immune dysregulation 427
EBV+ cutaneous B cell lymphoproliferative disorder of the elderly 430
Light microscopic findings 430
Phenotypic studies 430
Differential diagnosis 430
Pathogenesis 431
EBV-associated mucocutaneous ulcer 431
Light microscopic findings 431
EBV + T cell lymphoproliferative disease of the elderly 431
General principles regarding EBV-associated lymphomagenesis 431
Pathogenetic link between EBV-associated B cell lymphoma and iatrogenic immune dysregulation related to either methotrexate or cyclosporine 431
Case vignettes 433
Case vignette 1 433
Case vignette 2 435
Case vignette 3 437
Case vignette 4 438
References 442
20 Hodgkin Lymphoma of the Skin 445
Clinical features 445
Subtypes of Hodgkin lymphoma 446
Classic Hodgkin lymphoma 446
Lymphocyte-predominant Hodgkin lymphoma 446
Case vignettes 449
Case vignette 1 449
Additional molecular and cytogenetic studies 453
Case vignette 2 455
References 457
21 Chronic Lymphocytic Leukemia of B Cell and T Cell Prolymphocytic Leukemia 459
B cell chronic lymphocytic leukemia 459
Clinical features 459
Morphology 460
Phenotype 461
Molecular studies 461
Cytogenetics 461
Pathogenesis 462
T cell prolymphocytic leukemia 462
Pathologic abnormalities/light microscopic findings 463
Phenotypic abnormalities 463
Cytogenetics 463
Case vignettes 465
Case vignette 1 465
Case vignette 2 468
Case vignette 3 470
Case vignette 4 472
Case vignette 5 474
Case vignette 6 475
Additional molecular and cytogenetic studies 477
Additional case vignette 480
References 481
22 Adult T Cell Leukemia/Lymphoma 483
Clinical features 483
Pathology 484
Phenotypic studies 485
Pathogenesis 485
Infective dermatitis of childhood 486
Case vignettes 487
Case vignette 1 487
Case vignette 2 489
Case vignette 3 490
Case vignette 4 492
References 494
23 Angioimmunoblastic Lymphadenopathy/Angioimmunoblastic T Cell Lymphoma 496
Clinical features 496
Light microscopic findings 497
Phenotypic studies 498
Molecular studies 498
Pathogenesis 499
Case vignettes 501
Case vignette 1 501
Case vignette 2 504
Case vignette 3 505
Case vignette 4 506
References 507
24 Lymphomatoid Granulomatosis 509
Introduction 509
Clinical features 509
Histopathology 510
Histogenesis 511
Histogenesis 511
Clonality studies 511
Differential diagnosis 511
Treatment 512
Case vignette 513
Case vignette 1 513
References 516
25 Cutaneous Infiltrates of Myeloid Derivation 517
Introduction 517
Leukemia cutis 517
General overview 517
Light microscopic findings 519
Phenotypic studies 519
Clonal histiocytopathy syndromes 519
The ontogeny of the cutaneous dendritic cell 519
Langerhans cell histiocytosis/histiocytosis X 520
Classic Langerhans cell histiocytosis 521
Self-healing reticulohistiocytosis 521
Indeterminate cell histiocytosis 521
Langerhans cell sarcoma 522
Histiocytosis of myeloid dendritic cell origin (cutaneous myeloid dendritic cell dyscrasia/cutaneous monocytic dyscrasia) 523
The ontogeny and function of the myeloid dendritic cell 523
Histiocytopathy of factor XIII A perivascular dermal dendritic cell origin 524
Juvenile xanthogranuloma 524
Rosai–Dorfman disease 524
Xanthoma disseminatum 524
Generalized eruptive histiocytosis 525
Erdheim–Chester disease 525
Histiocytic sarcoma 525
Follicular and interdigitating dendritic cell sarcoma 526
Case vignettes 527
Case vignette 1 527
Case vignette 2 528
Case vignette 3 530
Case vignette 4 532
Case vignette 5 534
Case vignette 6 535
Case vignette 7 537
Case vignette 8 540
Case vignette 9 541
References 547
Index 551
EULA 569
| Erscheint lt. Verlag | 7.12.2015 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Schlagworte | Adult T Cell Leukemia • anaplastic large cell lymphoma • A. Neil Crowson • Angiommunoblastic T Cell Lymphoma • Benign Lymphocytic Infiltrates • Borderline CD-30 Lymphoproliferative Disease • CD-30 Positive Lymphoproliferative Disorders • CD4+ T-Cell lymphoma unspecified • Chronic Lymphocytic Leukemia of B-Cell • Cutaneous Infiltrates • Cutaneous Lymphoid Proliferation • Cutaneous Lymphoid Proliferations • Cutaneous Mantle Cell Lymphoma • Cutaneous T Cell Lymphoma • Cynthia M. Magro • Dermatologie • Dermatology • Epstein-Barr Virus Related lymphoproliferative disease • Hodgkin lymphoma • Intravascular Lymphoma • Jr. Classification of Lymphoma • Leg Type Precursor B Cell Lymphoblastic Lymphoma • Lymphocytic Infiltrates of the skin • Lymphoma Angiommunoblastic Lymphadenpathy (AILD) • Lymphomatoid Granulomatosis • Lymphomatoid Populosis • Marginal Zone Lymphoma • Martin C. Mihm • Medical oncology • Medical Science • Medizin • medizinische Onkologie • Molecular analysis • Mycosis Fungoides and Sezary Syndrome • Myloid Derivation • Onkologie • Pathologie • Pathology • Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin • Precursor Lesions of Cutaneous T Cell Lymphoma • Primary Cutaneous Diffuse Large B Cell Lymphoma • Primary Cutaneous Follicle Cell Lymphoma • Primary Cutaneous Hodgkin Lymphoma • Reactive Lymphoid Tissue Reactions • Subcutaneous Panniculitis-Like T Cell Lymphoma CD8 T Cell Nasal and Related Extra Nodal Natural Killer • T Cell Pro Lymphocytic Leukemia • T-Cell-Rich CD30 Positive Large B Cell Lymphoma |
| ISBN-10 | 1-118-77652-6 / 1118776526 |
| ISBN-13 | 978-1-118-77652-0 / 9781118776520 |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
| Haben Sie eine Frage zum Produkt? |
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