X-linked Mental Retardation

May/June 1988.

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In this comprehensive volume, an international group of experts offers a broad range of studies on the identification, occurrence, clinical manifestations and treatment of X-linked mental retardation syndromes. Using various genetic and physical approaches, 'X-Linked Mental Retardation 3' offers an in-depth analysis of these genetic disorders with significant studies on clinical aspects and nosology, prenatal diagnosis and treatment, cytogenetics, gene mapping, molecular basis, genetics and epidemiology and hypotheses of underlying causes. In particular, this important research sourcebook offers detailed explanations on: the puzzling recombinational variability around the fragile site; the imprinting theory or Laird model; clinical manifestations in the fra(x) syndrome and description of novel X-linked conditions; prenatal diagnosis of the fra(x) syndrome using amniotic fluid, chorionic villi, foetal blood, and molecular probes; cloning strategy of the fragile site; the linkage of the fra(x) site to the Martin Bell syndrome locus in a large number of informative families.