Advances in Immunology

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

1. Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules:  a New Hypothesis for Autoimmune Diseases Hisashi Arase 2. Mechanism of Diapedesis: Importance of the Transcellular Route Marie-Dominique Filippi 3. Evolution of the Humoral Response during HCV Infection: Theories of the Origin of Broadly Neutralizing Antibodies and Implications on Vaccine Design Armstrong Murira and Alain Lamarre 4. Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional  Control Ellen V. Rothenberg, Jonas Ungerbäck and Ameya Champhekar 5. Gene Map of the HLA Region, Graves’ Disease and Hashimoto Thyroidits, and Hematopoietic Stem Cell Translantation Takehiko Sasazuki, Hidetoshi Inoko, Satoko Morishima and Yasuo Morishima 6. The Pathogenesis and Immunobiology of Mousepox Luis J. Sigal 7. MAP4K Family Kinases in Immunity and Inflammation Huai-Chia Chuang, Xiaohong Wang and Tse-Hua Tan