The Genetic Basis of Haematological Cancers

Dr Sabrina Tosi graduated in Biological Sciences at the University of Milan (Italy) in 1989 and then attained her post-graduate degree in Human Cytogenetics at the University of Pavia (Italy) in 1992. Her interest in leukaemia dates back to 1989, when she started to work as a research scientist in the Department of Paediatric Haematology, Ospedale San Gerardo, Monza (Italy). In 1991-1992 Dr Tosi spent a year in the Oncogenetic Laboratory, Children's Hospital, University of Giessen (Germany) as a visiting research scientist. After another two years in Monza, Dr Tosi moved to the University of Oxford at the Weatherall Institute of Molecular Medicine, where she attained her DPhil in 1999 and spent altogether 12 years in leukaemia research. In 2005 she was appointed as Lecturer in Biosciences at Brunel University London, where she continues to work on the contribution of chromosomal abnormalities to leukaemia, with particular interest towards paediatric leukaemia. Dr Alistair Reid graduated in Genetics from the University of Newcastle upon Tyne in 1995, and trained as a diagnostic genetic scientist in the UK heath service. He obtained his PhD in Cambridge in 2003 based on the characterization of novel genetic prognosticators in myeloid leukemia. Since then he has held positions at several clinical academic haematology centres including Royal Free, London and University Children's Hospital, Zurich, and has also spent time as a consultant in the genetic diagnostics industry. In 2006 he was appointed Consultant Clinical Scientist in Molecular Pathology at Imperial College Healthcare Trust in London. He has an active laboratory-based translational research program focused on the genetics of myeloid leukemia and holds an honorary senior clinical lectureship for the development of novel methods of personalized genetic management in malignancy. Dr Reid has contributed to over 60 papers on malignancy genetics and was awarded fellowship of the Royal College of Pathologists in 2011.

Preface Chapter 1: Introduction Chapter 2: Molecular genetics of the myeloproliferative neoplasms Philip A Beer Chapter 3: Acute Myeloid Leukaemia Dr Matthew L Smith and Dr Thomas McKerrell Chapter 4: Molecular genetics of Pediatric Acute Myeloid Leukemia (AML) MM van den Heuvel-Eibrink, JDE de Rooij, and CM Zwaan Chapter 5: Acute Lymphoblastic Leukemia Anna Andersson, Anthony V. Moorman, Christine J. Harrison and Charles Mullighan Chapter 6: The Genetics of mature B-cell malignancies Jonathan C Strefford, Jude Fitzgibbon, Matthew JJ Rose-Zerilli and Csaba Bodor Chapter 7: The Genetics of Chronic Myelogenous Leukaemia Philippa C May, Jamshid S Khorashad, Mary Alikian, Danilo Perrotti and Alistair G Reid Index