Precision Molecular Pathology of Breast Cancer (eBook)

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2015 | 1st ed. 2015
X, 338 Seiten
Springer New York (Verlag)
978-1-4939-2886-6 (ISBN)

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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.

Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.



Ashraf Khan, MD, FRCPath
University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Ian O. Ellis, MD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Andrew M. Hanby, BM, FRCPath
St. James University Hospital/University of Leeds, Leeds Institute of Cancer and Pathology, Leeds, West Yorkshire, UK

Ediz F. Cosar, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Emad Rakha, MD, PhD, FRCPath
University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK

Dina Kandil, MD
UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA


This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2.Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Ashraf Khan, MD, FRCPathUniversity of Massachusetts Medical School, Department of Pathology, Worcester, MA, USAIan O. Ellis, MD, FRCPathUniversity of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UKAndrew M. Hanby, BM, FRCPathSt. James University Hospital/University of Leeds, Leeds Institute of Cancer and Pathology, Leeds, West Yorkshire, UKEdiz F. Cosar, MDUMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USAEmad Rakha, MD, PhD, FRCPathUniversity of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UKDina Kandil, MDUMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA

Chapter 1Molecular basis of breast cancer imagingGopal R. Vijayaraghavan, Srinivasan Vedantham , Ashraf Khan, Andrew KarellasChapter 2Familial Breast Cancer and Genetic Predisposition in Breast CancerVighnesh Walavalkar, Ashraf Khan, Dina KandilChapter 3Modelling the Molecular Pathology of Breast Cancer InitiationClaire Nash, Andrew M. Hanby, Valerie SpeirsChapter 4Molecular Pathology of Precancerous Lesions of the BreastAbhik Mukherjee, Ian O. Ellis, Emad A. RakhaChapter 5Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted TherapySanjoy Samanta, Ashraf Khan, Arthur M. MercurioChapter 6Molecular Pathology of Pre-Invasive Ductal CarcinomaYuna Gong, Dina Kandil, Ashraf KhanChapter 7Molecular Pathology of Lobular CarcinomaAli Sakhdari, Lloyd Hutchinson, Ediz CosarChapter 8Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic ImplicationsEmad A Rakha Chapter 9Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted TherapyLloyd Hutchinson, Ali Sakhdari, Ediz CosarChapter 10Molecular Classification of Breast CancerMohammed Aleskandarany, Ian O. Ellis, Emad A. RakhaChapter 11Triple Negative Breast Cancer: Subtypes with Clinical ImplicationsDina Kandil, Ashraf KhanChapter 12Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast CancerAbir A. Muftah, Mohammed Aleskandarany, Ian O. Ellis, Emad A RakhaChapter 13Role of MicroRNAs in Breast CancerJennifer M. Clarke, Dina Kandil, Ediz Cosar, Ashraf KhanChapter 14Molecular Pathology of Fibroepithelial Neoplasms of the BreastMichelle Yang, Dina Kandil, Ashraf Khan Chapter 15Molecular Features of Mesenchymal Tumors of the BreastMarjan Mirzabeigi, Ashraf Khan, Dina KandilChapter 16Molecular Pathology of Breast Cancer MetastasisMohammed Aleskandarany, Ian O. Ellis, Emad A. Rakha Chapter 17The molecular pathology of chemoresistance during the therapeutic response in breast cancerJames L Thorne, Andrew M. Hanby, Thomas A. HughesChapter 18The Molecular Pathology of Male Breast CancerRebecca A Millican-Slater, Valerie Speirs, Thomas A. Hughes, Andrew M. HanbyChapter 19Specimens for Molecular Testing in Breast CancerAli Sakhdari, Lloyd Hutchinson, Ediz Cosar

Erscheint lt. Verlag 12.8.2015
Reihe/Serie Molecular Pathology Library
Molecular Pathology Library
Zusatzinfo X, 338 p. 29 illus., 28 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Gynäkologie / Geburtshilfe
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Pathologie
Schlagworte Fibroepithelial Tumors • HER-2 Evaluation • Lobular Carcinoma • Mesenchymal Tumors • Precancerous Lesions • Pre-invasive Ductal Carcinoma
ISBN-10 1-4939-2886-4 / 1493928864
ISBN-13 978-1-4939-2886-6 / 9781493928866
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