Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of -amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. - Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development- Describes existing drugs for AD and current molecular understanding of the condition- Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
List of Contributors
A. Michael Crider United Arab Emirates University, Faculty of Medicine and Health Sciences, Department Pharmacology and Therapeutics, Al Ain, UAE
Abdu Adem Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE
Adel M. Abuzenadah King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia
Ali Jawad Department of Applied Physics, Zakir Husain College of Engineering and Technology, Aligarh Muslim University, Aligarh UP, India
Benjamin P. Repsold Pharmaceutical Chemistry, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa
Boris Decourt Banner Sun Health Research Institute, Sun City, AZ, USA
Carmen Martínez-Rincón Nursing Department, Complutense University of Madrid, Spain
Daniel Jun University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
Darrick Pope Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA
David F. Fischer BioFocus; Leiden, The Netherlands
David William Klaver Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
Dolores Rodríguez-Martínez Nursing Department, Complutense University of Madrid, Spain
Eric A. Owens Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303, USA
Eugenie Nepovimova Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Faizul H. Nasim Department of Chemistry, BJ Campus, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Fares Zeidán-Chuliá Center of Oxidative Stress Research, Department of Biochemistry, Postgraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Farhan Jalees Ahmad Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
Farzana L. Ansari Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Filip Zemek Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Giuseppina Tesco Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
Gjumrakch Aliev Department of Health Science and Healthcare Administration, University of Atlanta, Atlanta, GA, USA, and GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA
Iqbal Ahmad Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
Ismael Ortuño-Soriano Institute for Health Research at the San Carlos Clinical Hospital (IdISSC), Madrid, Spain; Nursing Department, Complutense University of Madrid, Spain
Jacobus P. Petzer Pharmaceutical Chemistry, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa
Jacques Joubert School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
Jan Korabecny Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Javed Ahmad Nanomedicine Research Lab, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
José Cláudio Fonseca Moreira Center of Oxidative Stress Research, Department of Biochemistry, Postgraduate Program in Biological Sciences: Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
José L. Pacheco-del-Cerro Nursing Department, Complutense University of Madrid, Spain
Julie Frearson BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, UK
Kamil Kuca University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
Kamil Musilek University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
Karin E. Sandoval Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA
Katarina Spilovska Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Kenneth A. Witt Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA
Lara Pacheco-Cuevas Nursing Department, Complutense University of Madrid, Spain
Louis H.A. Prins Department of Pharmacy, University of Namibia, Windhoek, Namibia
Maged M. Henary Department of Chemistry, Center for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, 30303, USA
Maria Kontoyianni Department of Pharmaceutical Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, USA
Marwan Sabbagh Banner Sun Health Research Institute, Sun City, AZ, USA
Mauricio Alcolea-Palafox Chemical-Physics Department, Chemistry Faculty, Complutense University of Madrid, Spain
Michael Cascio Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA
Michael D. Wall BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, UK
MiMi Macias Banner Sun Health Research Institute, Sun City, AZ, USA
Mohamed A. Embaby Department of Chemistry, Faculty of Sciences & Arts Khulais, King Abdulaziz University, Jeddah, KSA
Mohammad A. Kamal King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia
Mohammad Zaki Ahmad Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia
Nasimudeen R. Jabir King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia
Nigel H. Grieg Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Nighat Sultana Pharmaceutical Research Center, PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi 75280, Pakistan
Omar Aziz BioFocus; Chesterford Research Park, Saffron Walden, Essex, CB10 1XL,...
Erscheint lt. Verlag | 27.6.2015 |
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Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Naturwissenschaften ► Chemie | |
Technik | |
Wirtschaft | |
ISBN-10 | 0-12-803960-4 / 0128039604 |
ISBN-13 | 978-0-12-803960-1 / 9780128039601 |
Haben Sie eine Frage zum Produkt? |
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