Signal Transduction and Human Disease

Dr. Toren Finkel is Chief of the Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health (NIH, DHHS). He received his undergraduate training in physics and then completed a combined M.D./Ph.D. program at Harvard Medical School. Following graduation he pursued an internal medical residency at the Massachusetts General Hospital in Boston and a Cardiology Fellowship at Johns Hopkins School of Medicine in Baltimore. His laboratory has been interested in the role of oxidants as signaling molecules and the participation of free radicals in human disease. Dr. J. Silvio Gutkind is Chief of the Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH, DHHS). He received his Ph.D. in pharmacy and biochemistry from the University of Buenos Aires, Argentina. His laboratory has addressed the molecular basis of cancer by studying normal and aberrant functions of molecules involved in the transduction of proliferative signals. He also leads a multi-institutional effort aimed to elucidate the molecular changes that contribute to the evolution of squamous cell carcinomas.

Acknowledgments. Contributors.

Introduction.

1. Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals (Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel).

2. NF-kB:A Key Signaling Pathway in Asthma (Stewart J. Levine).

3. Molecular Mechanisms of Cancer (Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind).

4. Apoptotic Pathways in Cancer Progression and Treatment (Joya Chandra and Scott H. Kaufmann).

5. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes (Derek Le Roith, Michael J. Quon, and Yehiel Zick).

6. Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases (William F. Simonds).

7. Bacterial Regulation of the Cytoskeleton (Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo).

8. Bacterial Toxins and Diarrhea (Walter A. Patton, Joel Moss, and Martha Vaughan).

9. Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways (Roberta Visconti, Fabio Candotti, and John J. O’Shea).

10. Mast Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies (Michael A. Beaven and Thomas R. Hundley).

11. Rheumatology and Signal Transduction (Keith M. Hull and Daniel L. Kastner).

12. Molecular Mechanisms of Neurodegenerative Disorders (Benjamin Wolozin).

13. Neurotrophic Signaling in Mood Disorders (Jing Du,Todd D. Gould, and Husseini K. Manji).

14. Inhibiting Signaling Pathways Through Rational Drug Design (James N.Topper and Neill A. Giese).

Index.