Cataract - J.J. Harding

Cataract

Biochemistry, Epidemiology and Pharmacology

(Autor)

Buch | Hardcover
334 Seiten
1991
Chapman and Hall (Verlag)
978-0-412-36050-3 (ISBN)
374,49 inkl. MwSt
The author describes the structure, cellular composition, metabolism and proteins of the normal lens, then deals with the ageing lens, epidemiology of the cataract, experimental cataracts, human cataracts and how prevention eliminates the risks involved with surgery.
Cataract is the major cause of blindness in man throughout the world. It is usually dealt with by surgery but surgery is expensive and may lead to other ocular damage. Apart from surgery one might hope to prevent cataracts or to cure them, but these approaches require a much greater understanding of the structure and metabolism of the lens and of its weaknesses and strengths. The emphasis of this book is on recent findings. The first chapter deals with the normal lens and its structure, cellular composition, metabolism and proteins. In the following chapter the ageing of the lens will be discussed, and the third chapter discusses the epidemiology of cataract emphasizing the size of the problem of cataract and the associated risk factors. Surgery is discussed briefly but without detailed discussion of recent changes in surgical procedure. That is followed by a chapter on experimental cataracts and related in vitro studies. The studies of human cataracts are discussed in chapter 5. The last chapter deals with the prevention of cataract and its delay by anti-cataract agents.
There have been advances in this area recently and there is the promise of an effective therapeutic treatment soon.

Part 1 The normal lens: transparency; metabolism; crystallins; membrane and cytoskeletal proteins. Part 2 The ageing lens: physical changes; metabolic changes; changes to crystallins; changes to plasma membranes and cytoskeleton. Part 3 The epidemiology of cataract: the size of the problem; prevalence and incidence; case-control studies; diabetes; diarrhoe, malnutrition, poverty and sunlight; renal failure; hypertension and diuretics; myopia; miscellaneous risks; cataract and mortality. Part 4 Experimental opacification of the lens in vivo and in vitro: sugar cataract; radiation cataract; cynate, isocyanates, urea and cataract; steroid-induced cataract; selenite-induced cataract; genetic cataracts; calcium and opacification; oxidation and opacification; phase seperation opacification (cold cataract); miscellaneous cataracts; synergistic cataracts; common pathways to cataract. Part 5 Human cataract: physical changes; metabolic changes; changes to crystallins; changes to membranes; common pathways to human cataract. Part 6 Prevention and therapy: prevention by eliminating causes; anti-cataract agents.

Erscheint lt. Verlag 31.5.1991
Zusatzinfo X, 334 p.
Verlagsort London
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Augenheilkunde
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Zoologie
ISBN-10 0-412-36050-0 / 0412360500
ISBN-13 978-0-412-36050-3 / 9780412360503
Zustand Neuware
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