Radiopharmaceuticals for Therapy

F. F. (Russ) Knapp, Jr., Ph.D. Emeritus Program Manager Corporate Fellow ORNL Medical Radioisotope Program Nuclear Security and Isotope Division Bldg. 4501, MS 6229 Oak Ridge National Laboratory (ORNL) PO Box 2008 1 Bethel Valley Road Oak Ridge, TN 37830-6229 Dr. Ashutosh Dash Head, Isotope Production and Applications Division Professor, Homi Bhabha National Institute Bhabha Atomic Research Centre Mumbai, 400085, India

Chapter 1-Introduction-Radiopharmaceuticals Play an Important Role in both Diagnostic and Therapeutic Nuclear Medicine.- Chapter 2 – Therapeutic Radionuclides Decay with Particle Emission for Therapeutic Applications.- Chapter 3 - Alpha Radionuclide Therapy.- Chapter 4-Auger Electron-Based Radionuclide Therapy.- Chapter 5-Reactor-Produced Therapeutic Radionuclides.- Chapter 6-Accelerator-Produced Therapeutic Radionuclide.- Chapter 7-Radionuclide Generator Systems Represent Convenient Production Systems to Provide Therapeutic Radionuclides.- Chapter 8-Alpha-Emitting Radionuclide Production.- Chapter 9 - Radioimmunotherapy (RIT).- Chapter 10–Peptides for Receptor Radionuclide Therapy (PRRT).- Chapter 11-Therapeutic Radiopharmaceuticals for Treatment of Primary and Metastatic Hepatic Cancer.- Chapter 12-Therapeutic Radiopharmaceuticals for Bone Pain Palliation.- Chapter 13-Locoregional Radionuclide Therapy for Non-Melanoma Skin Cancer (NMSC).- Chapter 14-Radionuclide Synovectomy – Treatment of Inflammation of the Synovial Joints.- Chapter 15 - Inhibition of Arterial Restenosis following Balloon Angioplasty.- Chapter 16 - Moving Forward – Expected Opportunities for the Development of New Therapeutic Agents Based on Nano Technologies.- Chapter 17. Translation of Radiopharmaceuticals From Bench to Bedside – Regulatory and Manufacturing Issues.