Postgraduate Haematology

A. Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci Emeritus Professor of Haematology at University College London, London, UK.

Atul B. Mehta MA, MD, FRCP, FRC Path Consultant Haematologist & Clinical Director, RFH Lysosomal Storage Disorders Unit, Royal Free Hospital, London, UK

David Keeling Consultant in Haemophilia and Thrombosis, Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals, Oxford, UK

Douglas R. Higgs MD, FRCP, FRS Professor of Molecular Haematology & Director, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

Contributor list vii

Preface to the seventh edition x

Preface to the first edition xi

1 Stem cells and haemopoiesis 1
Emma de Pater, Elaine Dzierzak

2 Erythropoiesis 11
Douglas R Higgs, Noémi Roy, Deborah Hay

3 Iron metabolism iron deficiency and disorders of haem synthesis 21
Clara Camaschella, A Victor Hoffbrand, Chaim Hershko

4 Iron overload 40
Clara Camaschella, A Victor Hoffbrand, Maria Domenica Cappellini

5 Megaloblastic anaemia 53
A Victor Hoffbrand

6 Haemoglobin and the inherited disorders of globin synthesis 72
Swee Lay Thein, David Rees

7 Sickle cell disease 98
Anne Marsh, Elliott P Vichinsky

8 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 114
Paola Bianchi, Narla Mohandas

9 Acquired haemolytic anaemias 138
Modupe O Elebute, Rachel Kesse-Adu

10 Inherited aplastic anaemia/bone marrow failure syndromes 156
Inderjeet S Dokal

11 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 174
Judith CW Marsh, Austin G Kulasekararaj,, Neal S Young, Peter Hillmen

12 Red cell immunohaematology 195
Geoff Daniels, Marcela Contreras, Shubha Allard

13 Clinical blood transfusion 214
Shubha Allard, Marcela Contreras

14 Phagocytes 246
John Mascarenhas, Marina Kremyanskaya,, Ronald Hoffman

15 Lysosomal storage disorders 270
Atul B Mehta, Derralynn A Hughes

16 Normal lymphocytes and non-neoplastic lymphocyte disorders 278
Paul Moss, Mark Drayson

17 The spleen 303
Paul Moss

18 The molecular basis of haematological malignancies 314
Niccolo Bolli, George Vassiliou

19 Laboratory diagnosis of haematological neoplasms 332
Torsten Haferlach, Barbara J Bain

20 Acute myeloid leukaemia 352
Alan K Burnett, David Grimwade

21 Adult acute lymphoblastic Llukaemia 371
Clare J Rowntree, Adele K Fielding

22 Childhood acute lymphoblastic leukaemia 384
Ajay Vora

23 Supportive care in the management of leukaemia 399
Eliza Gil, Vanya Gant, Panagiotis Kottaridis

24 Chronic myeloid leukaemia 419
David TO Yeung, Timothy P Hughes

25 The myelodysplastic syndromes 438
Kavita Raj, Ghulam J Mufti

26 Myeloproliferative neoplasms 474
Peter J Campbell, Claire Harrison, Anthony R Green

27 Chronic lymphocytic leukaemia and other chronic B-cell disorders 500
Emili Montserrat, Peter Hillmen

28 T-cell lymphoproliferative disorders 524
Pier Luigi Zinzani, Alessandro Broccoli

29 Multiple myeloma 537
Jesús San-Miguel, Joan Bladé

30 Amyloidosis 562
Simon DJ Gibbs, Philip N Hawkins

31 The classification of lymphomas: updating the WHO classification 575
Elias Campo, Stefano A Pileri

32 Hodgkin lymphoma 601
Piers Blombery, David Linch

33 Non-Hodgkin lymphoma: low grade 614
William Townsend, Robert Marcus

34 Non-Hodgkin lymphoma: high grade 631
Jessica Okosun, Kate Cwynarski

35 Stem cell transplantation 651
Charles Craddock, Ronjon Chakraverty

36 Normal haemostasis 676
Keith Gomez, John H McVey

37 The vascular function of platelets 699
Stephen P Watson, Neil V Morgan, Paul Harrison

38 Haemophilia and VonWillebrand disease 715
Michael A Laffan, K John Pasi

39 Rare inherited coagulation disorders 733
Flora Peyvandi, Marzia Menegatti

40 Acquired coagulation disorders 743
Peter W Collins, Jecko Thachil, Cheng-Hock Toh

41 Congenital platelet disorders 761
Maurizio Margaglione, Paul RJ Ames

42 Primary immune thrombocytopenia 773
Drew Provan, Adrian C Newland

43 Thrombotic thrombocytopenic purpura and haemolytic–uraemic syndrome (congenital and acquired) 783
Pier Mannuccio Mannucci, Flora Peyvandi, Roberta Palla

44 Heritable thrombophilia 795
Trevor Baglin, David Keeling

45 Acquired venous thrombosis 809
Beverley J Hunt, Henry G Watson

46 Antithrombotic agents 820
Trevor Baglin, David Keeling

47 Management of venous thromboembolism 830
Trevor Baglin, David Keeling

48 Haematological aspects of systemic disease 838
A Victor Hoffbrand, Atul B Mehta

49 Haematological aspects of tropical diseases 854
Imelda Bates, Ivy Ekem

50 Neonatal haematology 870
Irene Roberts, Subarna Chakravorty

51 WHO Classification: Tumours of the Haematopoietic and Lymphoid Tissues (2008) 885

Index 888