The Retinoids (eBook)
608 Seiten
John Wiley & Sons (Verlag)
978-1-118-62790-7 (ISBN)
The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.
Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Pascal Dollé, M.D., Ph.D., is Team Leader and Department Head at the Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France Karen Niederreither, Ph.D, is an Associate Professor at the University of Strasbourg, School of Dentistry in Strasbourg, France, and performs research at the IGBMC, Illkirch, France
Contributors ix
Preface xiii
Part I: Vitamin A metabolic and enzymatic pathways 1
1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3
William S. Blaner and Yang Li
2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35
Earl H. Harrison and Carlo dela Senã's
3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57
Joseph L. Napoli and Charles R. Krois
4 Evolution of the Retinoic Acid Signaling Pathway 75
Vincent Laudet, Elisabeth Zieger, and Michael Schubert
Part II: Biochemistry and cellular biology of retinoic acid signaling 91
5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms 93
Marilyn Carrier and Cécile Rochette-Egly
6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117
Li-Na Wei
7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure-Function Relationships 131
William Bourguet and Dino Moras
8 How the RAR-RXR Heterodimer Recognizes the Genome 151
Sylvia Urban, Tao Ye, and Irwin Davidson
9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology 165
Marco-Antonio Mendoza-Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer
10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) "Orphan" Receptor 193
Marcia I. Dawson and Zebin Xia
11 The Dual Transcriptional Activity of Retinoic Acid 273
Noa Noy
12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291
Lorraine J. Gudas
Part III: RETINOIC ACID SIGNALING IN DEVELOPMENT 307
13 Retinoic Acid Signaling and Central Nervous System Development 309
Malcolm Maden
14 The Role of Retinoic Acid in Limb Development 339
Gregg Duester
15 Retinoic Acid Signaling and Heart Development 353
Stéphane Zaffran and Karen Niederreither
16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371
Wellington V. Cardoso and Felicia Chen
17 Retinoic Acid and the Control of Meiotic Initiation 383
Josephine Bowles and Peter Koopman
Part IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS 401
18 Retinoids and the Visual Cycle: New Actors for an "OLD" Function 403
Darwin Babino and Johannes von Lintig
19 Retinoid Signaling in the Central Nervous System 421
Peter McCaffery and Wojciech Krezel
20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449
A. Catharine Ross and Reza Zolfaghari
21 Retinoids and the Immune System 465
J. Rodrigo Mora and Makoto Iwata
22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation 485
Manuel Mark and Norbert B. Ghyselinck
Part V: RETINOIDS, DISEASE AND THERAPY 505
23 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507
Keith P. West, Jr.
24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529
Yaroslav Tsybovsky and Krzysztof Palczewski
25 Retinoic Acid in Acute Myeloid Leukemias 543
Hugues de Thé and Pierre Fenaux
26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557
Michael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky
Index 575
Erscheint lt. Verlag | 18.5.2015 |
---|---|
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Technik | |
Schlagworte | Biochemie • biochemistry • Biologie • Biowissenschaften • Cell & Molecular Biology • Clinical Pharmacology & Therapeutics • Klinische Pharmakologie u. Therapie • Life Sciences • Medical Science • Medizin • Retinoide • Zell- u. Molekularbiologie |
ISBN-10 | 1-118-62790-3 / 1118627903 |
ISBN-13 | 978-1-118-62790-7 / 9781118627907 |
Haben Sie eine Frage zum Produkt? |
Größe: 24,3 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: EPUB (Electronic Publication)
EPUB ist ein offener Standard für eBooks und eignet sich besonders zur Darstellung von Belletristik und Sachbüchern. Der Fließtext wird dynamisch an die Display- und Schriftgröße angepasst. Auch für mobile Lesegeräte ist EPUB daher gut geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich