Cardiovascular Toxicology, Third Edition

DANIEL ACOSTA, JR. is Dean of the College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA. He is the first and only Hispanic dean at the University of Cincinnati and the only Hispanic dean of pharmacy among the research-intensive colleges of pharmacy in the United States. Dr. Acosta is active in numerous scientific and professional organizations, serves on several editorial boards of toxicology and in vitro journals, and has been appointed to a number of government and private committees. He has been the recipient of many awards and honors, including the Burroughs Welcome Toxicology Scholar Award, the Foundation Award in Excellence from the Pharmaceutical Research and Manufacturers of America Foundation, and several endowed professorships from the University of Texas, where he taught for 22 years. He was also elected president of the Society of Toxicology from 2000 to 2001 and was recently honored with the 2005 Society of Toxicology’s Enhancement of Animal Welfare Award. At the University of Cincinnati, he has been a driving force in implementing a new entry-level Pharm.D. program, in addition to several new degree programs, including one of the first national masters programs in drug development.

Part I – Introduction.


Chapter 1: Advances in Cardiovascular Toxicology, Y. James Kang, Ph.D., DVM


Chapter 2: Pathobiology of Myocardial Ischemic Injury, L. Maximilian Buja, M.D.





Part II – Methods


Chapter 3: Nonclinical Safety Assessment of the Cardiovascular Toxicity of Drugs and Combination Medical Devices, Shayne C. Gad, Ph.D.


Chapter 4: Novel Approaches in the Evaluation of Cardiovascular Toxicity, Enrique Chacon, Ph.D., John J. Lemasters, M.D., Ph.D., Colleen Doherty, Ph.D., Joseph W. Starnes, Ph.D., and Vivek Kadambi, Ph.D.


Chapter 5: Cardiovascular Dynamics in Conscious Primates, Stephen F. Vatner, Ph.D., You-Tang Shen, M.D., and Franco Rossi, MSEE





Part III – Cardiotoxicity


Chapter 6: Cardiovascular Toxicity of Antimicrobials, Daniel P. Healy, Pharm.D.


Chapter 7: Cardiotoxicity of Anthracyclines and Other Antineoplastic Agents, Jane M. Pruemer, Pharm.D.


Chapter 8: Catecholamine-induced Cardiomyopathy, Naranjan S. Dhalla, Ph.D., M.D. and Melissa R. Dent, Ph.D.


Chapter 9: Adverse Effects of Centrally Acting Drugs on the Cardiovascular System, Mitchell S. Finkel, M.D., William F. Pettit, M.D. and Don Mishra, M.D.


Chapter 10: Adverse Effects of Drugs on Electrophysiological Properties of the Heart, Cynthia Carnes, Ph.D., Gary A. Gintant, and Robert L. Hamlin, DVM, Ph.D.


Chapter 11: Cardiovascular Effects of Steroidal Agents, Russell B. Melchert, Ph.D., Richard H. Kennedy, Ph.D., and Scott M. Belcher, Ph.D.


Chapter 12: Cardiotoxicity of Industrial Chemicals and Environmental Pollutants, Nachman Brautbar, M.D., John A. Williams, II, M.P.H., and Michael P. Wu, M.P.H.


Chapter 13: Adverse Effects of Cigarette Smoking on the Cardiovascular System, Stanton A. Glantz, Ph.D.





Part IV – Vascular Toxicity


Chapter 14: Overview of Vascular Toxicology, Kenneth S. Ramos, Ph.D. and E. Spencer Williams, Ph.D.


Chapter 15: Pathobiology of the Vascular Response to Injury, Peter G. Anderson, DVM, Ph.D.


Chapter 16: The Arterial Media as a Target of Injury by Chemicals, Paul J. Boor, M.D. and Daniel. J. Conklin, Ph.D.