Pharmacokinetics Made Easy, Revised

Don Birkett obtained his medical degree from Sydney University in 1967 and a D Phil in Biochemistry from Oxford University in 1970. He has been Professor and Head of CLinical Pharmacology at Flinders University of South Australia and Flinders Medical Centre since 1977. His major research interest has been in the field of drug metabolism using techniques ranging from in vitro molecular biological methods to in vivo pharmacokinetic studies. He was Chair of the International Union of Pharmacology (IUPHAR) Section on Drug Metabolism from 1994 to 1998. He has played a significant role in drug regulation, being a past member of the Australian Drug Evaluation Committee, and the current Chair of the Pharmaceutical Benefits Advisory Committee which considers the listing of drugs for government susidy in Australia. He also currently chairs the Australian Drug Utilization Subcommittee and the WHO Working Group on Drug Statistics Methodology. He has published more than 220 scientific papers and books. he has been teaching clinical pharmacology, pharmacology and pharmacokinetics for more than 25 years to medical and science students, and to drug regulators and members of the pharmaceutical industry.

Preface
About the authors

Definitions and Units of Symbols

Equations

Introduction


1.Clearance

2.Volume of Distribution

3.Half-life

4.How Drugs are Cleared by the Liver

5.Bioavailability and First-Pass Clearance

6.Predicting Drug Interactions and the Effects of Disease States for Metabolised Drugs

7.Clearance of Drugs by the Kidneys

8.Drug Protein Binding

9.Non-Linear Pharmacokinetics

10.How to Determine the Pharmacokinetic Parameters of a Drug

11.Pharmacodynamics-the Concentration-Effect Relationship

12.Designing Dose Regimens

13.Therapeutics Drug Monitoring


Answers