Pharmacology and Therapeutics in the New Millennium

Preface. 1. Endothelial Dysfunction and Vascular Disease; P.M. Vanhoutte. 2. Endothelin Receptors: Targets for drug development; A. Ray, et al. 3. Role of Endothelins in Cardiovascular Disease; L.C. Katwa. 4. The Diabetic Vasculature and Endothelin; D.A. Misurski, et al. 5. Beneficial Effects of Renin-Angiotensin System Blockade in Myocardial Infarction; N.S. Dhalla, X. Guo. 6. Role of Angiotensinogen in Human Hypertension; A. Kumar. 7. Biological Function of Cardiac High Molecular Weight Calmodulin-binding Protein; R. Kakkar, et al. 8. A Synthetic Calmodulin-binding Peptide Unmasks Crucial Calmodulin Control of the Calcium-Pumping ATPase in Cardiac Sarcoplasmic Reticulum; N. Narayanan, A. Xu. 9. Pharmacology of Vascular Adenosine Receptors; M.A.H. Talukder, et al. 10. Aquaretic Vasopressin Antagonists to Treat Chronic Hyponatremia; C.N. Corder, et al. 11. Regional Differences in the Regulation of L-type Calcium Current in Heart Cells; R. Kumar, et al. 12. Domoic Acid as a Tool in Molecular Pharmacology; S.K. Sharma, N.S. Dhalla. 13. Molecular Basis of Adapted Heart; D.K. Das, N. Maulik. 14. Gene Therapy and Renin-Angiotensin System; A.S. Pachori, et al. 15. Transgenic and Knockout Mouse Models in New Drug Discovery; V. Kumar. 16. Epidermal Growth Factor Receptor mRNA in Prostate: Clinical Implications and Hormonal Regulation; V.L. Kumar. 17. Angiogenesis: Concepts and Research Methodologies; S. Sengupta, S.K. Gupta. 18. Metabolism-Based Antifolate Drug Design: MDAM and MTREX; A. Amato, et al. 19. Angiogenesis: A New Approach to Glutamine Related Therapy; P. Maity, P. Bhattacharya. 20. Isolation and Characterization of Apoptosis Resistant Mutants: Molecular Targets for Chemoprevention; N. Singh, et al. 21. High Exposure to Caffeine-Derived N-Nitroso Compounds as Carcinogenic Risk for G.I.T. Cancers in Kashmir; M. Siddiqi. 22. Regulation of N-Myristoyl-transferase in Human Colon Cancer; R.V.S. Rajala, et al. 23. Differential Activation and Inhibition of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase Isozymes; R.K. Sharma. 24. Antioxidants in the Prevention of Hypercholesterolemic Atherosclerosis; P. Lee, K. Prasad. 25. Oxidative Stress and Aniline-Induced Splenic Toxicity; M.F. Khan, G.A.S. Ansari. 26. Efficacy of High Dose Multiple Antioxidants as an Adjunct to Standard Cancer Therapy; K.N. Prasad, et al. 27. Carotenoid/Retinol Dosage in Prevention/Treatment of Second Primary Cancer, Cyclical Mastodynia Syndrome and AIDS; L. Santamaria, A. Bianchi-Santamaria. 28. Complimentary Medicines and 21st Century Therapeutics: Challenges for Pharmacologists; D.B.A. Narayana, R.M. Dobriyal. 29. Strategies to Identify New Compounds and Pharmacological Activities from Traditional Herbal Medicines in Single and Combined Usage; I. Kimura, M. Kimura. 30. Plant-Derived Agents Against Cancer; F. Abdullaev. 31. Antidiabetic Effect of Viayasar (Pterocarpus marsupium); R.R. Chaudhury. 32. Development of Hepatoprotective Formulation from Plant Sources; S.S. Agrawal. 33. Kava <(Piper methysticum): From a Pacific Island Curiosity to a Herbal Superstar; Y.N. Singh. 34. Antiproliferative and Chemopreventive Potential of Indian Medicinal Plants, Withania somnifera and Ocimum sanctum; S.K. Gupta, J. Prakash. 35. Antiepileptic Drug Therapy in the New Millennium; Y.K. Gupta, J. Malhotra. 36. Neurochemical Abnormalities in the Hippocampal Formation with Schizophrenia; E. Scarr. 37. Changes in the Dopaminergic and Serotonergic Systems of the Prefrontal Cortex in Subjects with Schizophrenia: Evidence from Postmortem Stuides; B. Dean. 38. The Mammalian Metabotropic GABAGBPY/YGBP Receptor and Its Role; N.G. Bowery. 39. Signal-Transducing Activity of the Natriuretic Peptide C Receptor (NPR-C) in Neuronal Tissue; G.J. Trachte. 40. Carotenoid Interactions with Cellular Isoprenoid Pathways: A Common Mechanistic Theme for Diverse Biological Activities; W.C. Cole, K.N. Prasad. 14. Psychotherapeutic Implications of Cooperation and Control-Operations Among Multiple Opioid Receptors; K.K. Sharma, P.K. Mediratta. 42. Opioid Gastrointestinal Dependence; T.F. Burks, et al. 43. A Role for Calcium-Activated Neutral Proteinase in Myelin Protein Degradation Associated with Optic Neuritis and Multiple Sclerosis; D.C. Shields, N.L. Banik. 44. Myelin Galactosphingolipids as Negative Regulators of Differentiation; R. Bansal. 45. The Need for Pharmacovigilance; S. Olsson. 46. Pharmacovigilance and its Status in India; S.K. Gupta, U. Singh. 47. Pharmacovigilance and Detection of Signals; A. Misra, S. Sinha. 48. Reinforcing Drug Safety and Pharmacovigilance in Graduate Medical Curriculum; M. Thomas. 49. Treatment of Viral Pneumonia using a Combination of Antiviral and Antiinflammatory Medications; G.A. Prince. 50. Environmental Pollutants and Certain Therapeutic Agents Enhance the Severity of Virus Infection: Role of Cytokines; P. Seth, et al. 51. Inhibitory Effect of Interferon on Sexual Stages of Simian Malaria Parasites in Rhesus Monkeys; R. Tripathi, et al. 52. Therapeutic Strategies for Prevention of Cataract; S.K. Gupta, S. Joshi. 53. Reversal of Cholinergic Response of Intraocular Muscles by Atropine: Drug Antagonism Re-examined; P.N. Patil. 54. The Changing Target in the Treatment of Peptic Ulcer: From pH to Hp; U. Klotz. 55. Nitric Oxide and Peroxynitrite in Airway Disease; F.P. Nijkamp, G. Folkerts. 56. Therapeutic Agents for Benign Prostatic Hyperplasia: Achieving Pharmacological Selectivity; J.P. Hieble, A.C. Sulpizio. 57. Pharmacology Teaching, Learning and Testing at Academic Institutions; P.N. Patil. 58. Strategies for Reduction of Anthracycline Cardiac Toxicity; M.U.R. Naidu. 59. Cyclooxygenase Isoenzymes: Their Selective Inhibitors; S.K. Kulkarni, et al. 60. Contribution of the Clinical Pharmacologist to Control of Tropical Diseases; N.A. Kshirsagar, N.J. Gogtay. 61. Glutathione S-Transferases: Some New Functional Roles; U. Pandya, et al. 62. Catalytic Mechanism of mGSTA4-4, An Enzyme Involved in Response to Oxidative Stress; S.P. Singh, et al. 63. Xenobiotic Conjugates of Fatty Acids; B.S. Kaphalia, et al. 64. Aldose Reductase Efficeintly Detoxifies Lipid Derived Aldehydes; S.K. Srivastava, et al. 65. Identity of RLIP76 with the ATP-Dependent Transporter for Glutathione Conjugates and Doxorubicin in Human Tissues; S. Awasthi, et al. 66. The Protein Tyrosine Phosphatase Inhibitor Vanadyl Sulfate Prlongs Insulin-induced Activation of Mitogen-activated Protein Kinases ERK 1 and ERK 2 as well as Phosphatidylinositol-3-Kinase; J.-F. Theberge, et al. Index.