Pharmacogenomics
Crc Press Inc (Verlag)
978-0-8247-0544-2 (ISBN)
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"Summarizes the history of, and available applications, techniques, and approaches to, pharmacogenomics--improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design, and increasing the chances of successful clinical trials and patient outcomes. Compares pharmacogenomics to pharmacogenetics, focusing on the essential components that incorporate individual genetic variations to drug regimens resulting in different responses to therapeutics."
Historical aspects of pharmacogenomics; pharmacogenomics, biomarkers and the promise of personalized medicine; current status - pharmacogenetics/drug metabolism; pharmacogenetics -receptors; pharmacogenetics of drug transporters; interethnic differences in drug response; pharmacogenetics - clinical viewpoints; tools of the trade - the technologies and challenges of pharmacogenetics; molecular diagnostics and development of biotechnology-based diagnostics; technologies for the analysis of single-nucleotide polymorphisms - an overview; multiplex fluorescent minisequencing applied to the typing of genes encoding drug-metabolizing enzymes; multiplex genotyping by specialized mass spectrometry; serial analysis of gene expression -transcriptional insights into functional biology; proteomics; bioinformatics - WWW resources; applied bioinformatics; mapping of disease loci; positional cloning and disease gene identification; general conclusions and future directions.
Erscheint lt. Verlag | 8.5.2001 |
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Reihe/Serie | Drugs and the Pharmaceutical Sciences |
Verlagsort | Bosa Roca |
Sprache | englisch |
Gewicht | 771 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
ISBN-10 | 0-8247-0544-0 / 0824705440 |
ISBN-13 | 978-0-8247-0544-2 / 9780824705442 |
Zustand | Neuware |
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