Targeted Therapies for Solid Tumors -

Targeted Therapies for Solid Tumors (eBook)

A Handbook for Moving Toward New Frontiers in Cancer Treatment
eBook Download: PDF
2015 | 2015
X, 269 Seiten
Springer New York (Verlag)
978-1-4939-2047-1 (ISBN)
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This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature.

Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.



Antonio Russo, MD, PhD
University of Palermo, Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, Palermo, Italy

Rafael Rosell, MD, PhD
Hospital Germans Trias i Pujol, Catalan Institute of Oncology, Director, Cancer Biology & Precision Medicine Program, Badalona, Barcelona, Spain

Christian Rolfo, MD, PhD
Antwerp University Hospital, Phase I - Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp, Edegem, Antwerpen, Belgium


This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature.Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Antonio Russo, MD, PhDUniversity of Palermo, Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, Palermo, ItalyRafael Rosell, MD, PhD Hospital Germans Trias i Pujol, Catalan Institute of Oncology, Director, Cancer Biology & Precision Medicine Program, Badalona, Barcelona, SpainChristian Rolfo, MD, PhDAntwerp University Hospital, Phase I - Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp, Edegem, Antwerpen, Belgium

Chapter 1:  IntroductionAntonio Russo, Christian Rolfo, and Rafael RosellChapter 2: Oncogene Addiction in Solid TumorsStefano Caruso, Daniele FanaleChapter 3: Pharmacology and Clinical Development of New Molecularly Targeted AgentsElisa Giovannetti, Elena GalvaniChapter 4: Biomarkers as Prognostic, Predictive and Surrogate EndpointsFrancesco Passiglia, Giuseppe Cicero, Marta Castiglia, and Viviana BazanChapter 5: Evaluation of Response in Malignant Tumors Treated with Targeted AgentsGiuseppe Lo Re, Federica Vernuccio, Maria Cristina Galfano, Federico Midiri, and Massimo MidiriChapter 6: Targeted Therapies for HER2-Positive Breast CancerMaria Vittoria Dieci, Valentina Guarneri, Carlo Alberto Giorgi, and Pierfranco ConteChapter 7: Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC)Enrico Ricevuto, Katia Cannita, Gemma Bruera, Eleonora Palluzzi, Valentina Cocciolone, Corrado Ficorella, and Antonio Russo Chapter 8: Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck Pol SpecenierChapter 9: Targeted Therapies for NSCLCAntonio Russo, Christian Rolfo, Francesco Passiglia, and Rafael RosellChapter 10: Targeted Therapies for Gastric CancerNishi Kothari, Khaldoun AlmhannaChapter 11: Targeted Therapies for Pancreatic CancerLeón Mateos L, Grande Pulido E., and Antón Aparicio L. Chapter 12: Targeted Therapies in Hepatocellular CarcinomaFabrizio Bronte, Enrico Bronte, Giuseppe Bronte, and Vito Di MarcoChapter 13: Targeted Therapies for Colorectal CancerAntonio Russo, Antonio Galvano, Giuseppe Bronte, and Marc PeetersChapter 14: Targeted Therapy in Gastrointestinal Stromal Tumors Piotr Rutkowski, Joanna Przybyl, Agnieszka Wozniak, and Giuseppe BadalamentiChapter 15: Targeted Therapies in Kidney CancerAmparo Sánchez Gastaldo, Aránzazu González del Alba, and Ignacio DuránChapter 16: Targeted Therapies in MelanomaDaniele Fanale, Giuseppe Bronte, and Antonio RussoChapter 17: Targeted Therapies for Prostate CancerAránzazu González del Alba, Luis León; Cristina Suárez, and Maria José MéndezChapter 18: Targeted Therapies for Bone MetastasesDaniele Santini, Chiara Spoto, Vito Longo, Michele Iuliani, Alice Zoccoli, Salvatore Intagliata, Francesco Pantano, and Franco Silvestris

Erscheint lt. Verlag 11.3.2015
Reihe/Serie Current Clinical Pathology
Current Clinical Pathology
Zusatzinfo X, 269 p. 29 illus., 23 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Pathologie
ISBN-10 1-4939-2047-2 / 1493920472
ISBN-13 978-1-4939-2047-1 / 9781493920471
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