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RNA and DNA Diagnostics

Volker A. Erdmann, Stefan Jurga, Jan Barciszewski (Herausgeber)

Buch | Hardcover

X, 349 Seiten

2015 | 2015
Springer International Publishing (Verlag)
978-3-319-17304-7 (ISBN)

Lese- und Medienproben

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The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."

Electrochemical Biosensors for miRNA Detection.- Electrochemical Detection of RNA.- DNA and PNA probes for DNA Detection in Electroanalytical Systems.- DNA for Non-Nucleic Acid Sensing.- Aptamers in Oncotherapy.- Genotyping of Single Nucleotide Polymorphism.- Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.- Fluorescent Nucleic Acid Analogues in Research and Clinical Diagnostics.- Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures.- RNA and DNA Diagnostics on Microspheres: Current and Emerging Methods.- DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics.- Mechanochemical Sensing.- Microarrays as Research Tools and Diagnostic Devices.- Quadruplex Priming Amplification (QPA) for Nucleic Acid Diagnostics.- Single-molecule strategies for DNA and RNA diagnostics.- Detection and Assessment of microRNA Expression in Human Disease.

Erscheint lt. Verlag	29.6.2015
Reihe/Serie	RNA Technologies
Zusatzinfo	X, 349 p. 124 illus., 78 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Schlagworte	Aptamers • DNA and RNA targeted analyses • gene regulation • nucleic acid-based diagnostics • nucleic acids technologies
ISBN-10	3-319-17304-9 / 3319173049
ISBN-13	978-3-319-17304-7 / 9783319173047
Zustand	Neuware