Thomas' Hematopoietic Cell Transplantation

Stephen J. Forman, MD Chair, Department of Hematology and Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center Duarte, CA, USA Robert S. Negrin, MD Professor of Medicine Chief, Division of Blood and Marrow Transplantation Stanford University Stanford, CA, USA Joseph H. Antin, MD Professor of Medicine, Harvard Medical School Chief, Stem Cell Transplantation Dana-Farber/Brigham and Women's Cancer Center Boston, MA, USA Frederick R. Appelbaum, MD Member and Director, Clinical Research Division Fred Hutchinson Cancer Research Center Professor and Head, Division of Medical Oncology University of Washington School of Medicine Seattle, WA, USA

Robert S. Negrin, MD Professor of Medicine Chief, Division of Blood and Marrow Transplantation Stanford University Stanford, CA, USA

Joseph H. Antin, MD Professor of Medicine, Harvard Medical School Chief, Stem Cell Transplantation Dana-Farber/Brigham and Women's Cancer Center Boston, MA, USA

Frederick R. Appelbaum, MD Member and Director, Clinical Research Division Fred Hutchinson Cancer Research Center Professor and Head, Division of Medical Oncology University of Washington School of Medicine Seattle, WA, USA

Contributors, xi Preface to the First Edition, xvii Preface to the Fifth Edition, xviii Tribute, xix List of Abbreviations, xxii Section 1: History and Use of Hematopoietic Cell Transplantation 1 A History of Allogeneic and Autologous Hematopoietic Cell Transplantation, 1 Karl G. Blume and E. Donnall Thomas 2 Uses and Growth of Hematopoietic Cell Transplantation, 8 Mary M. Horowitz Section 2: Scientific Basis or Hematopoietic Cell Transplantation Section 2a: Hematopoiesis and Stem Biology Transplantation 3 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Pluripotent Stem Cells, 16 Laurence Daheron and David T. Scadden 4 Hematopoietic Stem Cells, Regenerative Medicine, and Leukemogenesis, 25 Irving Weissman 5 Marrow Microenvironment and Biology of Mobilization of Stem Cells, 50 Michael P. Rettig, Mark A. Schroeder and John F. DiPersio 6 Expansion of Human Hematopoietic Stem Cells, 62 Colleen Delaney 7 Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation, 69 Edwin M. Horwitz 8 Genetic Manipulation of Hematopoietic Stem Cells, 78 Jennifer E. Adair, Grant D. Trobridge and Hans-Peter Kiem Section 2b: Immunology 9 Overview of Hematopoietic Cell Transplantation Immunology, 96 Paul J. Martin and Warren D. Shlomchik 10 Histocompatibility, 112 Effie W. Petersdorf 11 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation, 126 Michael R. Verneris and Jeffrey S. Miller 12 Mechanisms of Tolerance, 136 Defu Zeng and Samuel Strober 13 The Pathophysiology of Graft-versus-Host Disease, 146 James L.M. Ferrara and Joseph H. Antin 14 Immune Regulation in Hematopoietic Cell Transplantation, 153 Robert S. Negrin and Jerome Ritz 15 Immune Reconstitution Following Hematopoietic Cell Transplantation, 160 Jarrod A. Dudakov, Miguel-Angel Perales and Marcel R.M. van den Brink 16 Biology of the Human Graft-versus-Tumor Response and How to Exploit It, 166 Edus H. Warren 17 Dendritic Cells in Hematopoietic Cell Transplantation, 178 Miriam Merad and Edgar G. Engleman 18 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 191 Judith A. Shizuru Section 2c: Technical Aspects 19 Pharmacologic Basis for High-dose Chemotherapy, 211 Borje S. Andersson, Benigno C. Valdez and Roy B. Jones 20 High-dose Preparatory Regimens, 223 William I. Bensinger 21 Reduced-intensity Allogeneic Transplantation Regimens, 232 Brenda M. Sandmaier and Rainer Storb 22 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 244 Jeffrey Y.C. Wong and Timothy Schultheiss 23 Radioimmunotherapy and Hematopoietic Cell Transplantation, 258 John M. Pagel and Ajay K. Gopal 24 Documentation of Engraftment and Characterization of Chimerism After Hematopoietic Cell Transplantation, 272 Paul J. Martin 25 The Detection and Significance of Minimal Residual Disease, 281 Merav Bar and Jerald P. Radich 26 Pathology of Hematopoietic Cell Transplantation, 292 Keith R. Loeb, Cecilia C. Yeung and Howard M. Shulman 27 Biostatistical Methods in Hematopoietic Cell Transplantation, 329 Joycelynne M. Palmer and Ted A. Gooley 28 Outcomes Research in Hematopoietic Cell Transplantation, 341 Stephanie J. Lee Section 3: Patient-oriented Issues in Hematopoietic Cell Transplantation 29 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 349 Bart L. Scott and Brenda M. Sandmaier 30 Nursing Role in Hematopoietic Cell Transplantation, 362 Rosemary C. Ford, Mihkaila M. Wickline and Diane Heye 31 Ethical Issues in Hematopoietic Cell Transplantation, 374 David S. Snyder 32 Psychosocial Issues in Hematopoietic Cell Transplantation, 384 Richard P. McQuellon and Katharine E. Duckworth 33 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients, 392 Karen L. Syrjala and Samantha Burns Artherholt 34 Sexuality Following Hematopoietic Cell Transplantation, 399 D. Kathryn Tierney 35 Hematopoietic Cell Transplantation: The Patient's Perspective, 407 Susan K. Stewart Section 4: Sources of Hematopoietic Cell for Hematopoietic Cell Transplantation 36 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation, 414 Phyllis I. Warkentin and Elizabeth J. Shpall 37 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries, 423 Dennis L. Confer, John P. Miller and Jeffrey W. Chell 38 The Role of the Transplant Program in a Nuclear Accident or Terrorism, 431 Nelson J. Chao and Dennis L. Confer 39 Cord Blood Hematopoietic Cell Transplantation, 437 Hal E. Broxmeyer, Sherif S. Farag and Vanderson Rocha 40 Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT, 452 Thomas C. Shea and John F. DiPersio 41 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation, 460 Norbert Schmitz and Peter Dreger 42 Cryopreservation of Hematopoietic Cells, 469 Scott D. Rowley 43 Use of Recombinant Growth Factors after Hematopoietic Cell Transplantation, 480 Jurgen Finke and Roland Mertelsmann 44 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors, 489 Claudio Anasetti, Franco Aversa and Andrea Velardi 45 Hematopoietic Cell Transplantation from Unrelated Donors, 505 Effie W. Petersdorf Section 5: Hematopoietic Cell Transplantation for Acquired Disease 46 Hematopoietic Cell Transplantation for Aplastic Anemia, 517 George E. Georges and Rainer Storb 47 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, 537 Ryotaro Nakamura 48 Hematopoietic Stem Cell Transplantation for Chronic Myeloid Leukemia, 545 Jerald P. Radich and Ravi Bhatia 49 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia, 554 Charlotte M. Niemeyer and Franco Locatelli 50 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia, 563 Frederick R. Appelbaum 51 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia, 576 Michael A. Pulsipher, Meghann McManus and Soheil Meshinchi 52 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults, 588 Stephen J. Forman 53 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children, 600 Parinda A. Mehta and Stella M. Davies 54 Hematopoietic Cell Transplantation for Myelodysplastic Syndromes and Myeloproliferative Neoplasms, 613 H. Joachim Deeg 55 Hematopoietic Cell Transplantation for Multiple Myeloma, 625 Amrita Krishnan and Sergio A. Giralt 56 Hematopoietic Cell Transplantation for Hodgkin Disease, 636 Philip J. Bierman and Auayporn Nademanee 57 Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma (B Cell), 653 Leslie L. Popplewell and Ginna G. Laport 58 Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma (T Cell), 664 Jasmine Zain and Sandra H. Thomas 59 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia, 675 Aaron C. Logan and David B. Miklos 60 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL-) Amyloidosis, 685 Heather J. Landau, Morie A. Gertz and Raymond L. Comenzo 61 Autologous Hematopoietic Cell Transplantation for Breast Cancer and Germ-cell Tumors, 700 Yago Nieto and Elizabeth J. Shpall 62 Hematopoietic Cell Transplantation for Renal Cell Carcinoma and Other Solid Tumors, 709 Richard W. Childs and Ramaprasad Srinivasan 63 Hematopoietic Cell Transplantation for Neuroblastoma, 721 Justin T. Wahlstrom and Katherine K. Matthay 64 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors, 729 Masanori Hayashi, David M. Loeb and Allen R. Chen 65 Hematopoietic Cell Therapy for Human Immunodeficiency Virus Infection, 742 Amrita Krishnan, Joseph Alvarnas, John J. Rossi and John A. Zaia 66 Hematopoietic Cell Transplantation for Autoimmune Diseases, 753 Richard A. Nash 67 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies, 765 Vinod Pullarkat and Stephen J. Forman 68 Adoptive T-cell Therapy for Viral Disease in the Setting of Hematopoietic Cell Transplantation, 777 Catherine M. Bollard and Helen E. Heslop 69 Adoptive T-cell Therapy for Malignancy in the Setting of Hematopoietic Cell Transplantation, 787 Stephen J. Forman, Michael Kalos and Carl H. June 70 Relapse of Hematologic Malignancy After Allogeneic Hematopoietic Transplantation, 797 Richard Champlin Section 6: Hematopoietic Cell Transplantation for Inherited Disease 71 Hematopoietic Cell Transplantation for Thalassemia, 803 Guido Lucarelli and Javid Gaziev 72 Hematopoietic Cell Transplantation for Sickle Cell Disease, 814 Mark C. Walters 73 Hematopoietic Cell Transplantation for Immunodeficiency Diseases, 827 Richard J. O'Reilly and Wilhelm Friedrich 74 Hematopoietic Cell Transplantation for Storage Diseases, 846 Joseph Rosenthal 75 Hematopoietic Cell Transplantation for Macrophage, Granulocyte and Osteoclast, Disorders, 871 Rajni Agarwal 76 Hematopoietic Cell Transplantation for Fanconi Anemia, 884 John E. Wagner, Jakub Tolar, Arleen D. Auerbach and Margaret L. MacMillan Section 7: Complications of Hematopoietic Cell Transplantation 77 Mechanisms and Treatment of Graft Failure, 905 Robert Lowsky and Hans Messner 78 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation, 916 Margaret R. O'Donnell 79 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation, 922 Jeffrey McCullough 80 Vascular Access and Complications, 937 I. Benjamin Paz 81 Pharmacologic Prevention of Acute Graft-versus-Host Disease, 951 Nelson J. Chao 82 T-cell Depletion to Prevent Graft-versus-Host Disease, 965 Robert J. Soiffer 83 Manifestations and Treatment of Acute Graft-versus-Host Disease, 973 Corey Cutler and Joseph H. Antin 84 Chronic Graft-versus-Host Disease Clinical Manifestations and Therapy, 981 Paul A. Carpenter, Mary E.D. Flowers and Steven Z. Pavletic 85 Bacterial Infections, 999 Helen L. Leather and John R. Wingard 86 Fungal Infections After Hematopoietic Cell Transplantation, 1018 Kieren A. Marr 87 Cytomegalovirus Infection, 1030 John A. Zaia 88 Herpes Simplex Virus Infections, 1039 Sanjeet S. Dadwal and James I. Ito 89 Varicella Zoster Virus Infections, 1046 Dora Y. Ho and Ann M. Arvin 90 Epstein Barr Virus Infection, 1066 Jennifer A. Kanakry and Richard F. Ambinder 91 Respiratory Viruses After Hematopoietic Cell Transplantation, 1073 Sachiko Seo and Michael Boeckh 92 HHV-6A, HHV-6B, HHV-7, and HHV-8 After Hematopoietic Cell Transplantation, 1083 Per Ljungman, Tetsushi Yoshikawa and Katherine N. Ward 93 Human Adenovirus, Polyomavirus, and Parvovirus Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation, 1090 Hans H. Hirsch and Steven A. Pergam 94 Gastrointestinal and Hepatic Complications, 1101 David M. Hockenbery, Simone I. Strasser and George B. McDonald 95 Lung Injury Following Hematopoietic Cell Transplantation, 1117 Kenneth R. Cooke and Gregory A. Yanik 96 Kidney and Bladder Complications of Hematopoietic Cell Transplantation, 1131 Sangeeta Hingorani 97 Endocrine Complications Following Hematopoietic Cell Transplantation, 1142 Fouad R. Kandeel and Behrouz Salehian 98 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation, 1167 Anne Poon and Lowan K. Ly 99 Nutrition Support of the Hematopoietic Cell Transplant Recipient, 1177 Paula Charuhas Macris and Kerry K. McMillen 100 Pain Management, 1186 Noelle V. Frey and Jonathan R. Gavrin 101 Oral Complications of Hematopoietic Cell Transplantation, 1203 Mark M. Schubert, Maria Elvira Pizzigatti Correa and Douglas E. Peterson 102 Growth and Development After Hematopoietic Cell Transplantation, 1218 K. Scott Baker and Anna Petryk 103 Delayed Non-malignant Complications After Hematopoietic Cell Transplantation, 1227 Smita Bhatia 104 Subsequent Malignant Neoplasms After Hematopoietic Cell Transplantation, 1236 Smita Bhatia and Ravi Bhatia 105 Neurologic Complications of Hematopoietic Cell Transplantation, 1248 Harry Openshaw and Bihong T. Chen 106 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients, 1258 Trudy N. Small Index, 1266