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Whooping Cough Due to Bordetella pertussis and other Bordetella Subspecies

James D. Cherry (Autor)

Buch | Hardcover

X, 190 Seiten

2023 | 1st ed. 2023
Springer International Publishing (Verlag)
978-3-319-16753-4 (ISBN)

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lt;p>Over the last century, interest in Bordetella pertussis and whooping cough has abounded at the same time as misunderstanding and misinformation about it proliferates and case numbers fluctuate. By the mid-twentieth century, B. pertussis was recognized and accepted as the cause of whooping cough, and newly developed vaccines were demonstrated to effectively prevent pertussis in children. Thousands of B. pertussis studies have since been carried out in mice, but over time further investigation has shown that the illness and its pathology in murine models is dissimilar from that of humans. Nevertheless, the findings in mice have led to the assumption by many Bordetella molecular microbiologists that their observations relate to human illness. The epidemiology B. pertussis infection is still not well understood by most epidemiologists and pertussis experts.

This book explores all aspects of B. pertussis and other Bordetella species that cause cough illnesses. It addresses the immunology, bacteriology, pathology, and serology, as well as the clinical epidemiology, public health considerations, diagnosis, treatment, and prevention of the clinical illnesses. The historical and evolutionary aspects of B. pertussis, B. holmesii and B. bronchiseptica infection and illness are also presented. The first complete book on whooping cough to be published in 80 years, this text is essential reading for medical students, researchers, and practitioners.

James D. Cherry, M.D., M.Sc., is Professor of Pediatrics at the David Geffen School of Medicine, UCLA, and Mattel Children's Hospital UCLA, Division of Infectious Diseases. He has spent more than 50 years in research, teaching, and clinical practice in the fields of infectious diseases and epidemiology. His laboratory experience has been in virology, mycoplasmology, and molecular microbiology relating to Bordetella species. Dr. Cherry's primary research has been related to vaccines and vaccine-preventable diseases, and the majority of his recent work relates to the epidemiology of Bordetella pertussis worldwide and its prevention by new vaccine strategies. At UCLA, he started the institution's first pediatric infectious diseases training program, and many of his trainees have gone on to become field leaders globally. Dr. Cherry is the author or co-author of over 550 publications, including The Textbook of Pediatric Infectious Diseases, now in its eighth edition (Elsevier, c. 2018). He is the recipient of numerous awards, including the Distinguished Physician Award from the Pediatric Infectious Diseases Society in 2003, the UCLA Medical Alumni Associations' Medical Science Award in 2005, and the IDSA's Alexander Fleming Lifetime Achievement Award in 2020.

PrefaceIntroduction
1. History
2. Phylogenetic Relationships between Bordetella Subspecies
3. Virulence Determinants and Molecular Pathogenesis3.1 Studies in Laboratory Media and Animals3.2 Virulence Determinants3.3 Molecular Pathogenesis/Pathology3.4 The Mechanisms of Leukocytosis in Pertussis
4. Epidemiology4.1 Reported Pertussis4.2 B. pertussis Infections
5. Clinical Manifestations of B. pertussis5.1 Asymptomatic Infections5.2 Unrecognized Infections/Illnesses5.3 Infants5.4 Adults
6. Differential Diagnosis of B. pertussis Illness6.1 Diagnosis7. The Prevention of Pertussis7.1 Quarantine7.2 Antimicrobial Prophylaxis
8. Treatment8.1 History8.2 Treatment in Young Infants8.3 Antimicrobial Agents for Specific Treatment
9. Immunization
10. International Pertussis/Bordetella Symposia
11. Other Bordetella That Cause Cough Illnesses in People
Figures and TablesReferences

Erscheint lt. Verlag	13.8.2023
Zusatzinfo	X, 190 p. 20 illus., 10 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Bordetella pertussis • cough illness • infectious disease • Vaccine • whooping cough
ISBN-10	3-319-16753-7 / 3319167537
ISBN-13	978-3-319-16753-4 / 9783319167534
Zustand	Neuware