Polyamines -

Polyamines (eBook)

A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism
eBook Download: PDF
2015 | 2015
IX, 336 Seiten
Springer Japan (Verlag)
978-4-431-55212-3 (ISBN)
Systemvoraussetzungen
149,79 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen

This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.


This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.

PART I BIOSYNTHESIS OF POLYAMINES,- 1 Biosynthesis of Polyamines in Eukaryotes, Archaea, and Bacteria.- 2 Long-Chain and Branched Polyamines in Thermophilic Microbes.- 3 Regulation and Diversity of Polyamine Biosynthesis in Plants.- PART II CATABOLISM OF POLYAMINES.- 4 Polyamine Catabolism in Prokaryotes.- 5 Mammalian Polyamine Catabolism.- 6 Polyamine Catabolism in Plants.- PART III POLYAMINE HOMEOSTASIS.- 7 Antizyme.- 8 Bacterial Antizyme.- 9 Polyamine Homeostasis in Plants: The Role(s) of Evolutionarily Conserved Upstream ORFs.- PART IV ROLES OF POLYAMINES IN GROWTH.- 10 Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A.- 11 The Polyamine Modulon: Genes Encoding Proteins Whose Synthesis Is Enhanced by Polyamines at the Level of Translation.- 12 Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression.- PART V ROLES OF POLYAMINES IN SURVIVAL.- 13 Polyamines in Plant Stress Response.- PART VI POLYAMINE TRANSPORTERS.- 14 Recent Advances in Bacterial Polyamine Transport Systems.- 15 Polyamine Transport Systems in Plants.- PART VII POLYAMINE-DERIVED SECONDARY METABOLITES.- 16 Polyamine-Derived Alkaloids in Plants: Molecular Elucidation of Biosynthesis.- 17 Polyamine Toxins from Spiders and Wasps.- PART VIII ACTION OF POLYAMINES ON ION CHANNELS.- 18 Polyamine Block of Inwardly Rectifying Potassium (Kir) Channels.- 19 Polyamine Action on Plant Ion Channels and Pumps.- 20 Regulation of N-Methyl-d-Aspartate Receptors by Spermine and Ifenprodil.- PART IX POLYAMINES AND LONGEVITY.- 21 Polyamines and Longevity in Mammals.- 22 Polyamine Interactions with Plant Hormones: Crosstalk at Several Levels.- PART X DIAGNOSIS AND DRUG TARGETS.- 23 N1, N12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion.- 24 Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa.

Erscheint lt. Verlag 7.1.2015
Zusatzinfo IX, 336 p. 66 illus., 28 illus. in color.
Verlagsort Tokyo
Sprache englisch
Themenwelt Studium 1. Studienabschnitt (Vorklinik) Physiologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte biosynthesis • Catabolism • homeostasis • Ion channel • Longevity • Transport
ISBN-10 4-431-55212-X / 443155212X
ISBN-13 978-4-431-55212-3 / 9784431552123
Haben Sie eine Frage zum Produkt?
PDFPDF (Wasserzeichen)
Größe: 9,5 MB

DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasser­zeichen und ist damit für Sie persona­lisiert. Bei einer missbräuch­lichen Weiter­gabe des eBooks an Dritte ist eine Rück­ver­folgung an die Quelle möglich.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Zusätzliches Feature: Online Lesen
Dieses eBook können Sie zusätzlich zum Download auch online im Webbrowser lesen.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich

von Hans-Christian Pape; Armin Kurtz; Stefan Silbernagl

eBook Download (2023)
Georg Thieme Verlag KG
109,99

von Hans-Christian Pape; Armin Kurtz; Stefan Silbernagl

eBook Download (2023)
Georg Thieme Verlag KG
109,99