Fluorescence Imaging for Surgeons

Fernando Dip, MD, MAACThe Bariatric and Metabolic InstituteSection of Minimally Invasive SurgeryDepartment of General and Vascular SurgeryCleveland Clinic FloridaWeston, FL  USAAndOncological Surgical Division, Department of SurgeryDivision of Surgical ResearchHospital de Clinicas Buenos AiresUniversity of Buenos AiresBuenos Aires, ArgentinaTakeaki Ishizawa, MD, PhD, FACSDepartment of Gastroenterological Surgery, Cancer Institute Hospital Japanese Foundation for Cancer Reserach Koto-ku, Tokyo JapanAndHepato-Biliary-Pancreatic Surgery Division, Department of SurgeryGraduate School of Medicine, The University of TokyoBunkyo-ky, TokyaJapanNorihiro Kokudo, MD, PhD, FACSProfessor and ChairmanHepato-Biliary-Pancreatic Surgery Division, Department of SurgeryGraduate School of Medicine, The University of TokyoBunkyo-ky, TokyaJapanRaul J. Rosenthal, MD, FACSChief of StaffThe Bariatric & Metabolic InstituteSection of Minimally Invasive Surgery Department of General & Vascular Surgery Cleveland Clinic Florida Weston, FL USA

Section I: Background.- Basic Concepts of Fluorescence and Fluorescent Probes.- Past, Present, and Future of Fluorescence.- Translation of Therapeutic Antibodies for Intraoperative Fluorescence Imaging.- Review of Indocyanine Green Imaging in Surgery.- Section II: Imaging Systems.- D-Light P System (Karl Storz) (with video).- Robotic Surgery Using Firefly System.- Fluorescence Imaging Systems (PDE, HyperEye Medical System, and Prototypes in Japan).- The Pinpoint System.- Economic Impact of Fluorescent Cholangiography.- Real-time Near-Infrared Fluorescent Cholangiography During Robotic Single-Site Cholecystectomy.- Fluorescent Guided Liver Surgery: Paul Brousse Experiences and Perspective.- Fluorescence Imaging in Laparoscopic Hepatectomy (with video).- Section III: Clinical Applications of Intraoperative Fluorescence Imaging.- Identification of Hepatic Segment (with video).- Intraoperative Evaluation of Regional Portal Uptake Function (with video).- Identification of Hepatocellular Carcinoma (with video).- Identification of Metastatic Liver Cancer (with video).- Prediction for Postoperative Intrahepatic Recurrence of Hepatocellular Carcinoma.- Detection of Bile Leakage after Hepatic Resection by Intraoperative Indocyanine Gren Flourescent Imaging.- Near-Infrared Laser Photodynamic Therapy for Human Hepatocellular Carcinoma Cell Line Tumor with Indocyanine Green Fluorescene.- Photodynamic Diagnosis of Gastric Cancer Using 5-Aminolevulinic Acid (with video).- Applications of ICG Fluorescence Imaging for Surgery in Colorectal Cancer.- Fluorophore-Conjugated Chimeric Anti-CEA Antibodies for Fluorescence-Guided Surgery of Gastrointestinal (GI) Tumors.- Development of a Non-Blurring, Dual-Imaging (X-ray/Fluorescence) Tissue Marker for Localization of Gastrointestinal Tumors.- Sentinel Node Navigation Surgery by Infrared Imaging in Gastric Cancer.- A Dual Infrared Ray Imaging System for Sentinel Node Mapping Against Early Gastric Cancer: Absorption andFlorescence Methods by Infrared Ray Electronic Endoscopy Combined with Indocyanine Green.- Indocyanine Green Fluorescence-Navigated Sentital Node Biopsy Showed Higher Sensitivity than the Conventional Radioisotope or Blue Dye Methods: It May Help to Reduce False-Negative Sentinel Lymph Node Biopsies in Skin Cancer.- The Indocyanine Green Method is Equivalent to ther (99m) Tc-Labeled Radiotracer Method for Identifying the Sentinel Node in Breast Cancer: A Concordance and Validation Study.- Photodynamic Detection of Lymph Node Metastases in Gastronintestinal Cancer by Using 5-Aminolevulinic Acid.- Application of Photodynamic Treatment (with video).- Photodynamic Diagnosis Mediated by 5-Aminolevulinic Acid for Urinary Bladder Cancer (with video).- Real-time Assessment of Intestinal Perfusion by Fluorescence-Based Enhanced Reality.- Fluorescent Angiography for Flap Planning and Monitoring in Reconstructive Surgery.- Fluorescein-Detection of Myocardial Ischemia in an Experimental Model of Acute Coronary Occlusion.- Spatial and Temporal Monitoring of Perfusing with Indocyanine Green Videoangiography in Rat Heart.- Ureter Identification Using Methylene Blue and Fluorescein.- Chymotrypsin Probe for Real-Time Visualization of Pancreatic Leak.