GERD

Dr. Parakrama Chandrasoma was born in Sri Lanka and received his medical education and initial pathology training in the Medical School of the University of Sri Lanka. He has postgraduate degrees in internal medicine, including the M.D. (Sri Lanka) and Membership of the Royal College of Physicians (UK). He immigrated to the United States in 1978. Upon completing his pathology residency, he assumed duties as Chief of Surgical Pathology at the Los Angeles County + University of Southern California Medical Center He has held this position since. After an initial interest in neuropathology, Dr. Chandrasoma joined Dr. Tom DeMeester's Foregut Surgery team as pathologist in 1991. This led to a productive study of gastroesophageal reflux disease spanning 16 years and resulting in the development of numerous original concepts relating to the pathogenesis of gastroesophageal reflux disease. Dr. Chandrasoma has written over 140 peer reviewed papers and 6 previous pathology textbooks, including a general text on Gastrointestinal Pathology and a text on Gastroesophageal Reflux Disease, and is a Professor of Pathology at the Keck School of Medicine at the University of Southern California. He is married with three children and lives in Pasadena, California.

PROPOSED TABLE OF CONTENTS--
Chapter 1: The history of Barrett's esophagus
Chapter 2: The Importance of Gastroesophageal Reflux
Chapter 3: Clinical Manifestations of Reflux Disease
Chapter 4: Definitions
Chapter 5: Development of Esophagus and Stomach and Cell Kinetics
Chapter 6: Normal Anatomy and Physiology of the Esophagus
Chapter 7: Gastricization - end-stage esophagus
Chapter 8: The lower esophageal sphincter and reflux
Chapter 9: Gastroesophageal Reflux and early changes in squamous epithelium
Chapter 10: Columnar transformation of the esophagus - Reflux carditis
Chapter 11: Evolution of Cardiac mucosa
Chapter 12. Injurious elements in the gastric refluxate
Chapter 13. Oxynto-cardiac mucosa: the Parietal cell
Chapter 14. Intestinal Metaplasia
Chapter 15: Intestinal Metaplasia of the Gastric Cardia
Chapter 16: Treatment of Reflux Disease
Chapter 17: Effect of Treatment on metaplastic columnar epithelium
Chapter 18: The Neoplastic transformation of intestinal metaplasia
Chapter 19: Adenocarcinoma induced by Reflux
Chapter 20: Treatment of adenocarcinoma of the Esophagus
Chapter 21: Pathologic assessment of the resected specimens
Chapter 22: The Future