Glycosylation and Cancer

Dr. Drake is a Professor in the Department of Cell and Molecular Pharmacology and Experimental Therapeutics at the Medical University of South Carolina and SmartState Endowed Chair in Proteomics. He is an experienced protein biochemist and glycobiologist, with particular expertise in tumor biology and biomarker discovery from clinical fluids and tissues related to urological cancers and other cancers. He obtained his Ph.D. in Biochemistry at the University of Kentucky with Boyd Haley, generating multiple nucleotide sugar photoaffinity analogs for use in the study of glycosyltransferases. More extensive glycobiology training was done in post-doctoral work with Alan Elbein, and he began his academic career in Dr. Elbein’s department at the University of Arkansas for Medical Sciences. Currently, his research focus is on direct analysis of glycans and glycolipids in tissues using state-of-the-art MALDI mass spectrometry imaging approaches. Complementary glycopeptide mass spectrometry and metabolic labeling targeted approaches are being done to identify specific glycoproteins involved in the epithelial-to-mesenchymal transition.

1. Glycosylation and Cancer: Moving Glycomics to the Forefront
Richard R. Drake
2. Role of N-glycans in cancer Biomarker, Progression and Metastasis, and Therapeutics   
Naoyuki Taniguchi  and Yasuhiko Kizuka
3. Simple Sugars to Complex Disease – Mucin-type O-glycans in Cancer
Matthew R. Kudelka, Tongzhong Ju, Jamie Heimburg-Molinaro, and Richard D. Cummings
4. Intracellular Protein O-GlcNAc Modification Integrates Nutrient Status with Transcriptional and Metabolic Regulation
Alexis K. Nagel and Lauren E. Ball
5. The Detection and Discovery of Glycan Motifs in Biological Samples Using Lectins and Antibodies: New Methods and Opportunities
Huiyuan Tang, Peter Hsueh, Doron Kletter, Marshall Bern, and Brian Haab
6. Glycosylation Characteristics of Colorectal Cancer
Stephanie Holst, Manfred Wuhrer and Yoann Rombouts
7. Glycosylation and Liver Cancer
Anand Mehta, Harmin Herrera and Timothy Block
8. Functional Impact of Tumor-Specific N-linked Glycan Changes in Breast and Ovarian Cancers
Huabei Guo and Karen Abbott
9. Glycosylation Alterations in Lung and Brain Cancer
Hassan Lemjabbar-Alaoui, Andrew McKinney, Yi-Wei Yang, Vy M. Tran and  Joanna J. Phillip
10. Altered Glycosylation in Prostate Cancer
Richard R. Drake, E. Ellen Jones, Thomas W. Powers and Julius O. Nyalwidhe