The Lung

Kent Pinkerton, MD, is professor of pediatrics, School of Medicine, and director of the Center for Health and the Environment at the University of California, Davis. His research focuses on the health effects of inhaled environmental air pollutants to alter respiratory, cardiovascular, and neurological structure and function. Special areas of interest include the interaction of gases and airborne particles to produce cellular and structural changes within site-specific regions and cells of the respiratory tract in both acute and chronic timeframes of exposure. Recent studies have focused on environmental and biological impacts of synthesized nanomaterials as well as the effects of environmental tobacco smoke and combustion particles on lung growth and development. He is associate director for the San Joaquin Aerosol Health Effects Research Center (SAHERC) to study airborne particles of the San Joaquin Valley. He is also the associate director for the Western Center for Agricultural Health and Safety (WCAHS) to study the health effects of airborne particles in an agricultural setting. Richard Harding is a NHMRC Senior Principal Research Fellow and an Emeritus Professor with the Department of Anatomy and Developmental Biology at Monash University, Australia. His research focuses on Respiratory Development and Programming. He is now semi-retired.

Preface
Introduction

CRITICAL EVENTS IN NORMAL DEVELOPMENT AND AGING
Lung Morphogenesis, role of growth factors and transcription factors
Development of Airway Epithelium
Development of the Airway Innervation
Development of Alveoli
Development of the Pulmonary Basement Membrane
Development of the Pulmonary Vascular
Developmental Physiology of the Pulmonary Circulation
Development of Fluid Transport Across Pulmonary Epithelia
Physical, Endocrine and Growth Factors in Lung Development
Development of the Pulmonary Surfactant System
Development of the Pulmonary Immune System
Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems
Compensatory Lung Growth
Pulmonary Transition at Birth
Normal Aging of the Lung

ENVIRONMENTAL INFLUENCES ON LUNG DEVELOPMENT AND AGING
Pulmonary Consequences of Premature Birth
Role of Nutrition in Lung Development Before and After Birth
Influence of High Altitude on Lung Development and Function
Genetic Factors Involved in Susceptibility to Lung Disease
Effects of Environmental Tobacco Smoke on Lung Development
Nicotine Exposure During Early Development- effects on the lung
Exposure to Allergens During Development
Development of Atopy in Children
Effects of Air Pollution on Lung Function Development and Asthma Occurence
Environmental Toxicants and Lung Development in Experimental Models
Repair of Environmental Lung Injury During Development
Effects of Aging, Disease and the Environment on the Pulmonary Surfactant System
Environmental Determinants of Lung Aging