Chemotherapy of Bacterial Infections (eBook)

Front Cover 1
Chemotherapy of Bacterial Infections: Part I 4
Copyright Page 5
Table of Contents 10
Contributors 6
Preface 8
Contents of Volume I 14
Contents of Volume III 16
Contents of Volume IV 18
Chapter 1. 
20 
I. Early History of Antibacterial Chemotherapy 20
II. Antibacterial Action of Acridine Dyestufïs 24
III. Other Dyestufïs 46
REFERENCES 49
Chapter 2. 
56 
I. Introduction 56
II. Structure and Function in Bacterial and Mammalian Cells 58
III. The Action of Sulfonamides 64
IV. The Action of the Penicillins 75
V. Other Antibiotics Which Affect Cell Wall Synthesis 86
REFERENCES 89
Chapter 3. 
98 
I. Introduction: The Problem of Specificity 98
II. The Different Levels of Chemotherapy 101
III. Some Specific Examples of the Relation of Structure to Function in Antibacterial Drugs 115
IV. Conclusions 127
REFERENCES 127
Chapter 4. 
132 
I. Introduction 133
II. Historical Considerations: Trends in Research on Resistance to Therapeutically Useful and Useless Substances and Conditions 135
III. Heat-Resistant and Thermophilic Bacteria 136
IV. Organisms Growing in High Sugar and Salt Concentrations 139
V. Radiation Resistance 144
VI. Resistance to Acid and Alkaline Conditions 148
VII. Resistance to Heavy Metals 152
VIII. Resistance to Certain Enzyme Inhibitors 160
IX. Resistance to Surface-Active Agents and Lytic Enzymes 162
X. Resistance to Certain Other Disinfectants and Preservatives 168
XI. 
170 
XII. Concluding Remarks 172
REFERENCES 176
Chapter 5. Antibacterial Chemotherapy with Sulfonamides 188
PART 1. HISTORICAL SURVEY 189
I. Introduction 189
II. Development of Sulfonamides 190
PART 2. SULFONAMIDE ACTION IN VITRO 200
I. Methods 203
II. Bacteristatic Effect of Newer Sulfonamides 214
III. Discussion of the in Vitro Tests with Sulfonamides 225
PART 3. SULFONAMIDE ACTION IN VIVO 227
I. Experimental Procedures 228
II. Results of in Vivo Experiments 236
III. Correlation of in Vitro and in Vivo Experiments 250
IV. Concluding Remarks 254
ACKNOWLEDGMENT 255
REFERENCES 255
Chapter 6. 
268 
I. Introduction 268
II. Pharmacology 269
III. Synergists, Potentiators, and Antagonists Including Combinations with Other Drugs 312
IV. Toxicology 314
ADDENDUM 320
REFERENCES 321
Chapter 7. 
326 
I. Introduction 326
II. Synthesis 328
III. Properties of the Nitrofurans 328
IV. Summary 377
ACKNOWLEDGMENT 377
REFERENCES 378
Chapter 8. 
390 
I. Introduction 390
II. Compounds with Predominantly Local Activity 390
III. Compounds with Systemic Activity 401
REFERENCES 408
Chapter 9. 
412 
I. Introduction 412
II. Basic Biologic Principles 413
III. Techniques for Detection and Measurement of Chemotherapeutic Activity 422
IV. Chemotherapeutic Effect of Active Compounds 457
V. Other Mycobacterial Infections 482
VI. Conclusion 486
ACKNOWLEDGMENTS 487
REFERENCES 487
Chapter 10. 
520 
I. Human Leprosy (Hansen's Disease) 520
II. Mycobacterium leprae (Hansen's Bacillus) 524
III. Murine Leprosy 530
IV. Screening Procedures with Mycobacterium lepraemurium 535
V. Chemotherapeutic Activity of Antileprosy Agents 539
REFERENCES 561
Author Index 578
Subject Index 610