The Nervous System (eBook)

Front Cover 
1 
The Nervous System: Central Nervous System Drugs, Part B 4
Copyright Page 5
Table of Contents 12
Contributors to Volume II 6
Foreword to Volume I 8
Preface 10
Contents of Volume III 14
PART I: DEPRESSANT DRUGS (Continued) 18
G. Relaxants of Skeletal Muscle 18
I. INTRODUCTION 19
II. NEUROPHYSIOLOGICAL SUBSTRATE OF DRUG ACTION 20
III. PHARMACOLOGICAL PROPERTIES OF SELECTED MUSCLE RELAXANTS 31
IV. COMMENTS ON THERAPEUTIC USEFULNESS 87
REFERENCES 90
H. Anticonvulsant Drugs 114
I. INTRODUCTION 114
II. CLINICAL AND EXPERIMENTAL SEIZURES 116
III. ANTICONVULSANTS AND THEIR MECHANISMS 146
IV. DEFINITIVE SEIZURE MECHANISMS 179
REFERENCES 182
Chapter I. Antitussive Drugs 192
I. GENERAL CONSIDERATIONS 192
II. THE PATHOPHYSIOLOGY OF COUGH 193
III. PHARMACODYNAMIC CHARACTERISTICS OF ANTITUSSIVES 197
IV. CONCLUDING REMARKS 205
APPENDIX: METHOD OF SEARCHING FOR AGENTS HAVING SELECTIVE EFFECTS ON ACTIVE EXPIRATORY PROCESSES 206
ACKNOWLEDGMENTS 214
REFERENCES 214
Chapter II. Psychic Energizers and Antidepressant Drugs 218
I. INTRODUCTION 218
II. MONOAMINE OXIDASE INHIBITORS 223
III. IMINODIBENZYL DERIVATIVES 245
IV. THE PHYSIOLOGICAL AND PHARMACOLOGICAL BASIS OF THE CLINICAL TREATMENT OF DEPRESSIONS 254
REFERENCES 261
Chapter III. Emetic and Antiemetic Drugs 272
I. INTRODUCTION 273
II. NEURAL MECHANISM OF EMESIS 274
III. EMETIC AGENTS 286
IV. EMETIC SYNDROMES 310
V. ANTIEMETIC AGENTS 316
REFERENCES 332
Chapter IV. The Effects of Drugs upon the Eye 346
I. UNIQUE OPHTHALMIC FACTORS 346
II. THE EFFECT OF DRUGS USED IN THE THERAPY OF OCULAR DISEASE 351
III. UNDESIRABLE EYE EFFECTS OF OPHTHALMIC AND OTHER DRUGS 393
IV. UNDESIRABLE SYSTEMIC EFFECTS OF OPHTHALMIC DRUGS 399
REFERENCES 401
Chapter V. Synoptic Transmission in the Central Nervous System 416
I. INTRODUCTION 416
II. THE STRUCTURE OF CENTRAL SYNAPSES 417
III. THE ELECTROPHYSIOLOGY OF SYNAPSES 421
IV. CHEMICAL TRANSMITTERS IN THE CENTRAL NERVOUS SYSTEM 433
V. TRANSMITTER RELEASE 441
REFERENCES 443
Author Index 450
Subject Index 477