The Nervous System (eBook)

Front Cover 1
The Nervous System, Part D 4
Copyright Page 5
Table of Contents 10
CONTRIBUTORS TO VOLUME IV 6
FOREWORD 8
CONTENTS OF PREVIOUS VOLUMES 14
Part III: Adrenergic Drugs 18
Chapter A. The Effects of Adrenergic Drugs on the Heart 18
I. Introduction 18
II. Possible Drug Actions on the Heart 21
III. Actions of the Adrenergic Drugs 25
IV. Summary and Conclusions 38
References 39
Chapter B. The Effects of Adrenergic Drugs on the Systemic Circulation 46
I. Introduction 46
II. Epinephrine and Arterenol 47
III. Other Sympathomimetic Drugs 79
References 98
Chapter C. The Effects of the Adrenergic Compounds on the Pulmonary Circulation 114
I. Introduction and Physiologic Considerations 114
II. The Adrenergic Compounds: General Considerations 117
References 140
Chapter D. The Effects of Adrenergic Agents on Smooth Muscles Other Than Those of the Vascular System 146
I. Introduction 146
II. The Intestine 147
III. Uterine Muscle 164
IV. The Nictitating Membrane 177
References 190
Chapter E. The Effects of Sympathomimetic Amines and Adrenergic Blocking Agents on Metabolism 196
I. Introduction 196
II. Effects on Carbohydrate Metabolism 197
III. Effects on Fat Metabolism 208
IV. Effects on Oxygen Consumption 217
V. Effects on Cations 225
References 230
Part IV: Adrenergic Blocking Drugs 260
Chapter A. Blockade of a-Adrenergic Receptors 260
I. Introduction 260
II. Major Groups of a-Adrenergic Blocking Agents 262
III. Responses of Various Effector Systems to a-Adrenergic Blockade 274
IV. Therapeutic Use of a-Adrenergic Blockade 300
References 308
Chapter B. Blockade of ß-Adrenergic Receptors 324
I. Introduction 324
II. Direct Effects of ß-Receptor Blocking Compounds 327
III. Specificity of ß-Receptor Blockade 328
IV. Effects of Catecholamines on Physiological Systems After ß-Receptor Blockade 329
V. The Antiarrhythmic Action of ß-Receptor Blocking Compounds 336
VI. Application of ß-Receptor Blocking Compounds 339
References 341
Part V: The Veratrum Alkaloids 348
I. Introduction 348
II. The Chemistry of Veratrum Alkaloids 350
III. Pharmacological Actions 356
IV. Therapeutic Use 400
References 403
Part VI: Neurotoxins 416
I. Introduction 416
II. Botulism 417
III. Tetanus 435
IV. Animal Neurotoxins 444
References 459
AUTHOR INDEX 478
SUBJECT INDEX 518