Screening Methods in Pharmacology (eBook)

Front Cover 1
Screening Methods in Pharmacology 4
Copyright Page 5
Table of Contents 6
List of Contributors 10
Preface 12
Contents of Volume I 14
Introduction 16
Chapter 1. a-Adrenergic Blocking Agents 22
I. General Considerations 22
II. Methods 25
References 39
Chapter 2. ß-Adrenergic Blocking Agents 42
I. Introduction 42
II. Methods of Screening for ß-Adrenergic Blocking Agents 47
III. Classification of New ß-Adrenergic Blocking Agents 56
IV. Metabolic Effects of ß-Adrenergic Blocking Agents 58
V. Comparison of Methods 60
VI. Use of ß-Adrenergic Blocking Agents in Therapy 60
References 60
Chapter 3. Agents Acting on Coronary Blood Vessels 62
I. Introduction 62
II. Isolated Organs 63
III. Measurement of Coronary Blood Flow of the Heart in Situ 64
IV. Experimental Coronary Insufficiency 73
V. Concluding Remarks 78
References 80
Chapter 4. Agents with Kinin-like Activity 82
I. Introduction 82
II. Methods for Assaying Components of the Plasma Kinin System 85
References 93
Chapter 5. Androgenic and Anabolic Agents 96
I. Introduction 96
II. Methods 98
References 104
Chapter 6. Estrogenic and Antiestrogenic Agents 106
I. Introduction 106
II. Screening Methods for Estrogens 110
III. Screening Methods for Antiestrogens 119
References 121
Chapter 7. Anovulatory Agents 122
I. Introduction 122
II. Screening Assays 124
References 125
Chapter 8. Progestational Agents 126
I. Introduction 126
II. Screening Methods for Progestational Agents 127
III. General Comments 139
References 139
Chapter 9. Antihyperlipidemic Agents 142
I. Introduction 143
II. Historical Review 143
III. Etiology 144
IV. Therapy in Atherosclerosis 147
V. Screening Methods 150
References 161
Chapter 10. Immunosuppressive Agents 166
I. Introduction 166
II. Screening Procedures 171
References 184
Chapter 11. Agents Affecting Mucociliary Activity 188
I. Introduction 188
II. In Vitro Methods 192
III. In Vivo Methods 212
References 223
Chapter 12. Antiperspirant Agents 224
I. Introduction 224
II. Methods 225
References 229
Chapter 13. Antidepressant Agents 230
I. Introduction 231
II. Antagonism of the Effects of Reserpine-like Drugs 234
III. Potentiation of Phenethylamines 236
IV. Muricide Antagonism in Rats 238
V. Effects of Antidepressants on the Autonomie Nervous System 239
VI. Inhibition of Norepinephrine Uptake and Release 241
VII. Monoamine Oxidase Inhibition 243
References 245
Chapter 14. Agents with Analgesic Activity and Dependence Liability 248
I. Introduction 248
II. Analgesic Evaluation 251
III. Characterization for Abuse Potential 255
References 266
Chapter 15. Natriuretic and Antihypertensive Agents Screened by Sequential Methods 270
I. Introduction 270
II. The Design of a Sequential Procedure 
271 
III. Use of Controls 274
IV. Examples of Design and Use of Sequential Procedures 275
References 286
Author Index 288
Subject Index 300