Prostanoids (eBook)

Front Cover 1
Prostanoids 4
Copyright Page 5
Table of Contents 6
Preface 8
CHAPTER 1. SYNTHESIS AND PHARMACOLOGY OF NEW PROSTACYCLIN ANALOGUES 
10 
Introduction 10
Material and methods 11
Chemistry 11
Pharmacology 11
Results 11
Discussion 13
Summary 14
References 17
CHAPTER 2. 
18 
Summary 21
References 22
CHAPTER 3. 
24 
Introduction 24
Materials and methods 25
Results 29
Discussion 32
Summary 32
References 33
Acknowledgement 34
CHAPTER 4. MODULATION OF PROSTAGLAND IN BIOSYNTHESIS BY D-PENICILLAMINE AND GOLD DERIVATIVES 
36 
INTRODUCTION 36
MATERIAL AND METHODS 38
RESULTS 40
COMMENTS 40
SUMMARY 43
REFERENCES 43
CHAPTER 5. 3-/1-PRAZ0LYL/-PYRIDAZINE DERIVATIVES WITH PROSTAGLANDIN A ISOMERASE INHIBITING EFFECT 46
MATERIALS AND METHODS 46
RESULTS AND DISCUSSION 47
SUMMARY 48
REFERENCES 48
CHAPTER 6. 
50 
Introduction 50
Material and methods 52
Results 54
Discussion 54
Summary 55
References 56
CHAPTER 7. 
58 
Materials and method 58
Results 59
Discussion 61
Summary 62
References 63
CHAPTER 8. THE EFFECT OF OESTRONE AND PROGESTERONE ON PROSTAGLANDIN METABOLISM IN BRAIN 
64 
Materials and Methods 65
Results 66
Discussion 69
References 70
CHAPTER 9. INTERACTION OF SODIUM SALICYLATE AND INDOMETHACIN IN RATS AS SHOWN BY PROSTACYCLIN RELEASE FROM GASTRIC MUCOSA 
72 
Material and Methods 72
Results 73
Discussion 76
Summary 77
References 78
CHAPTER 10. 
80 
Material and Methods 80
Results 81
Comments 88
Summary 88
References 89
CHAPTER 11. 
90 
Introduction 90
Material and methods 90
Results 91
Discussion 95
Summary 96
References 96
CHAPTER 12. 
98 
Introduction 98
Material and Methods 98
Results 99
Discussion 101
References 102
CHAPTER 13. SEX DIFFERENCES IN CARDIOVASCULAR ACTIVITY OF PCI2 AND 6 ß -PCI1 104
Introduction 104
Methods 105
Results 105
Discussion 107
Summary 108
References 108
CHAPTER 14. 
110 
Introduction 110
Material and Methods 110
Results 111
Discussion 113
Summary 117
References 117
CHAPTER 15. INFLUENCE OF LINOLEIC ACID DEFICIENT DIET ON PG METABOLISM AND BLOOD PRESSURE OF SALT LOADED RATS AFTER CHEMICAL SYMPATHECTOMY 
120 
Introduction 120
Material and Methods 120
Results 121
Comments 125
Summary 126
References 127
CHAPTER 16. CHANGES IN PROSTAGLANDIN BIOSYNTHESIS IN SPONTANEOUSLY HYPERTENSIVE RATS AFTER ADMINISTRATION OF ANTIHYPERTENSIVE DRUGS 130
INTRODUCTION 130
METHODS 130
RESULTS AND DISCUSSION 131
SUMMARY 134
REFERENCES 135
CHAPTER 17. 
136 
Summary 136
Introduction 136
Material and Methods 137
Animals 137
cAMP and ATP levels in platelets 137
cAMP and ATP levels in aortic tissue 138
Sensitivity of platelets to ADP and collagen 138
Determination of atherosclerotic plaque formation 138
Results 138
Basal ATP levels in platelets and aortic tissue 139
Sensitivity of platelets to ADP and collagen 140
Formation of atherosclerotic plaques 140
Discussion 141
References 142
CHAPTER 18. 
144 
MATERIALS AND METHODS 145
RESULTS AND DISCUSSION 146
SUMMARY 154
REFERENCE 154
CHAPTER 19. ACTIONS OF PROSTACYCLIN (PGI2) ON ISOLATED GUINEA-PIG VAS DEFERENS AND RABBIT PULMONARY,MESENTERIC AND EAR ARTERIES 
156 
Introduction 156
Material and Methods 156
Results and Conclusions 157
References 158
CHAPTER 20. PROSTACYCLIN - CLINICAL IMPLICATIONS OF BIOLOGICAL ACTIONS 1 
160 
Introduction 160
Material and methods 162
Results 163
Discussion 164
Summary 167
References 167
CHAPTER 21. 
170 
Materials and methods 170
In vitro investigations 170
Materials 171
Results 171
Discussion 173
Summary 174
Literature 175
CHAPTER 22. 
176 
Material and methods 176
Results 177
Discussion 178
Summary 181
References 181
SUBJECT INDEX 182