Mycotoxins in Foodstuffs - 3 -

Mycotoxins in Foodstuffs - 3 (eBook)

Invited Lectures Presented at the Third International IUPAC Symposium on Mycotoxins in Foodstuffs, Paris, France, 16 - 18 September, 1976

M. Jemmali (Herausgeber)

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2017 | 1. Auflage
81 Seiten
Elsevier Science (Verlag)
978-1-4831-5780-1 (ISBN)
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Mycotoxins in Foodstuffs-3 is a collection of invited lectures presented at the International Union of Pure and Applied Chemistry's Third International Symposium on Mycotoxins in Foodstuffs, held in Paris, France, on September 16-18, 1976. The papers explore the health hazards posed by mycotoxins found in foodstuffs, including aflatoxins and trichothecenes, as well as ways of addressing the problem. This book is comprised of 11 chapters and begins with a discussion on how to design a program for monitoring problem foods and surveying potential problem foods for a number of mycotoxins. The next chapter describes a methodology for the design and evaluation of testing programs to estimate aflatoxin concentrations in granular foodstuffs. The action taken by various countries regarding mycotoxins in foodstuffs (food and feed), under legislative provision or code of practice, is then examined. Subsequent chapters deal with the metabolism of aflatoxin and other mycotoxins in relation to their toxicity and the accumulation of residues in animal tissues; mode of action of trichothecenes; and mode of action and human health aspects of aflatoxin carcinogenesis. The human health hazards associated with mycotoxins are also considered, along with prevention, elimination, and detoxification of aflatoxins. This monograph will be a useful resource for chemists, nutritionists, food scientists, and toxicologists.
Mycotoxins in Foodstuffs-3 is a collection of invited lectures presented at the International Union of Pure and Applied Chemistry's Third International Symposium on Mycotoxins in Foodstuffs, held in Paris, France, on September 16-18, 1976. The papers explore the health hazards posed by mycotoxins found in foodstuffs, including aflatoxins and trichothecenes, as well as ways of addressing the problem. This book is comprised of 11 chapters and begins with a discussion on how to design a program for monitoring problem foods and surveying potential problem foods for a number of mycotoxins. The next chapter describes a methodology for the design and evaluation of testing programs to estimate aflatoxin concentrations in granular foodstuffs. The action taken by various countries regarding mycotoxins in foodstuffs (food and feed), under legislative provision or code of practice, is then examined. Subsequent chapters deal with the metabolism of aflatoxin and other mycotoxins in relation to their toxicity and the accumulation of residues in animal tissues; mode of action of trichothecenes; and mode of action and human health aspects of aflatoxin carcinogenesis. The human health hazards associated with mycotoxins are also considered, along with prevention, elimination, and detoxification of aflatoxins. This monograph will be a useful resource for chemists, nutritionists, food scientists, and toxicologists.

Front Cover 1
Mycotoxins in Foodstuffs—3 4
Copyright Page 5
Table of Contents 6
CHAPTER 1. 
8 
Abstract 8
DESIGN OF A SURVEY 8
MONITORING PROGRAMS 10
REFERENCES 12
CHAPTER 2. 
14 
Abstract 14
INTRODUCTION 14
MATHEMATICAL AND THEORETICAL CONSIDERATIONS 16
EVALUATION OF A PEANUT TESTING PROGRAM 18
DISCUSSION 22
REFERENCES 22
CHAPTER 3. 
24 
Abstract 24
INTRODUCTION 24
TOLERANCES IN FOODSTUFFS 24
REFERENCES 26
CHAPTER 4. METABOLISM OF AFLATOXIN AND OTHER MYCOTOXINS IN RELATION TO THEIR TOXICITY AND THE ACCUMULATION OF RESIDUES IN ANIMAL TISSUES 28
Abstract 28
INTRODUCTION 28
AFLATOXIN 30
STERIGMATOCYSTIN 32
OCHRATOXIN A 32
TRICHOTHECENES 32
ZEARALENONE 34
OESTROGENIC TOXINS AND PSEUDO-STEROIDS 34
EXTRA-HEPATIC METABOLIC ACTIVATION 34
REFERENCES 36
CHAPTER 5. MODE D' ACTION DES MYCOTOXINES 38
Abstract 38
INTRODUCTION 38
MECANISME DE L'ACTION TOXIQUE DE L'AFLATOXINE B1 ET DE LA PR TOXINE 38
MYCOTOXINES ET CANCEROGENICITE 40
REFERENCES 41
CHAPTER 6. 
42 
Abstract 42
INTRODUCTION 42
RESULTS AND DISCUSSIONS 42
Acknowledgement 49
REFERENCES 49
CHAPTER 7. 
52 
Abstract 52
REFERENCES 56
CHAPTER 8. SHORT-TERM TESTS AND MYCOTOXINS 58
Abstract 58
CHAPTER 9. 
64 
Abstract 64
INTRODUCTION 64
PREVENTION: AGRICULTURAL PRACTICES 64
DIVERSION 65
ANTIFUNGAL AGENTS 65
GENETIC APPROACHES 65
ELIMINATION: REMOVAL BY PHYSICAL SEPARATION 66
DETOXIFICATION 67
REFERENCES 68
CHAPTER 10. 
70 
Abstract 70
REFERENCES 74
CHAPTER 11. 
76 
Abstract 76
INTRODUCTION 76
COMPOUNDS WHICH ACT UPON THE CENTRAL NERVOUS SYSTEM (CNS) 76
TOXIC CYTOCHALASINS 78
BISDIHYDROBENZOFURAN METABOLITES 79
MYCOTOXINS WHICH CONTAIN THE ß-TRICARBONYL MOIETY 80
HIGHLY OXYGENATED COMPOUNDS 81
CYCLIC PEPTIDES 82
CONCLUSION 82
REFERENCES 82

Erscheint lt. Verlag 7.4.2017
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
ISBN-10 1-4831-5780-6 / 1483157806
ISBN-13 978-1-4831-5780-1 / 9781483157801
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